Evidence map›Paper›PMID 31804488›Full record

ArticleNature communications2019

Cryo-EM structure of the human MLL1 core complex bound to the nucleosome.

Sang Ho Park, Alex Ayoub, Young-Tae Lee, Jing Xu, Hanseong Kim, Wei Zheng, Biao Zhang, Liang Sha, Sojin An, Yang Zhang and 4 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 67 citations in OpenAlex.

  1. Multiscale modeling primer: Focus on chromatin and epigenetics.The Journal of biological chemistry · 2026
    Review
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  3. Article
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  5. Article
  6. Review
  7. Article
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  9. Review
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  12. Loss-of-function in RBBP5 results in a syndromic neurodevelopmental disorder associated with microcephaly.Genetics in medicine : official journal of the American College of Medical Genetics · 2024
    Article
  13. Review
  14. Article
  15. Review
  16. Recent Progress of Protein Tertiary Structure Prediction.Molecules (Basel, Switzerland) · 2024
    Review
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Sang Ho ParkDepartment of Biological Chemistry, University of Michigan, Ann Arbor, Michigan, 48109, USA.ORCID http://orcid.org/0000-0003-3323-763X
Alex AyoubDepartment of Pathology, University of Michigan, Ann Arbor, Michigan, 48109, USA.
Young-Tae LeeDepartment of Pathology, University of Michigan, Ann Arbor, Michigan, 48109, USA.
Jing XuDepartment of Pathology, University of Michigan, Ann Arbor, Michigan, 48109, USA.
Hanseong KimDepartment of Biological Chemistry, University of Michigan, Ann Arbor, Michigan, 48109, USA.ORCID http://orcid.org/0000-0001-7518-6936
Wei ZhengComputational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, 48109, USA.ORCID http://orcid.org/0000-0002-2984-9003
Biao ZhangComputational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, 48109, USA.
Liang ShaDepartment of Pathology, University of Michigan, Ann Arbor, Michigan, 48109, USA.
Sojin AnDepartment of Biological Chemistry, University of Michigan, Ann Arbor, Michigan, 48109, USA.
Yang ZhangDepartment of Biological Chemistry, University of Michigan, Ann Arbor, Michigan, 48109, USA.
Michael A CianfroccoDepartment of Biological Chemistry, University of Michigan, Ann Arbor, Michigan, 48109, USA.
Min SuLife Sciences Institute, University of Michigan, Ann Arbor, Michigan, 48109, USA.
Yali DouDepartment of Biological Chemistry, University of Michigan, Ann Arbor, Michigan, 48109, USA. yalid@med.umich.edu.ORCID http://orcid.org/0000-0002-4040-1429
Uhn-Soo ChoDepartment of Biological Chemistry, University of Michigan, Ann Arbor, Michigan, 48109, USA. uhnsoo@med.umich.edu.ORCID http://orcid.org/0000-0002-6992-2455
University of Michigan · US

Funding

Function of MLL in transcription regulationR01GM082856 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DOU, YALI · 2009 to 2023
$4.0M
The molecular mechanisms of nutrient- and stress-dependent mTORC1 regulation mediated by human Sestrin2.R01DK111465 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHO, UHN-SOO · 2016 to 2020
$2.4M
NIDDK NIH HHS R01 DK111465NIGMS NIH HHS R01 GM082856
6 · The paper itself

Abstract

Mixed lineage leukemia (MLL) family histone methyltransferases are enzymes that deposit histone H3 Lys4 (K4) mono-/di-/tri-methylation and regulate gene expression in mammals. Despite extensive structural and biochemical studies, the molecular mechanisms whereby the MLL complexes recognize histone H3K4 within nucleosome core particles (NCPs) remain unclear. Here we report the single-particle cryo-electron microscopy (cryo-EM) structure of the NCP-bound human MLL1 core complex. We show that the MLL1 core complex anchors to the NCP via the conserved RbBP5 and ASH2L, which interact extensively with nucleosomal DNA and the surface close to the N-terminal tail of histone H4. Concurrent interactions of RbBP5 and ASH2L with the NCP uniquely align the catalytic MLL1

Indexed as

AnimalsCell NucleusCryoelectron MicroscopyDNA-Binding ProteinsHistone-Lysine N-MethyltransferaseHistonesHumansLysineMethylationMutationMyeloid-Lymphoid Leukemia ProteinNuclear ProteinsNucleosomesProtein BindingTranscription FactorsXenopus laevisASH2L protein, humanDNA-Binding ProteinsHistone-Lysine N-MethyltransferaseHistonesKMT2A protein, humanLysineMyeloid-Lymphoid Leukemia ProteinNuclear ProteinsNucleosomesRBBP5 protein, humanTranscription Factors

Identifiers

PMID31804488
PMCPMC6895043
OpenAlexW2993736794

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.