Evidence map›Paper›PMID 31804481›Full record

ArticleNature communications2019

Superhydrophobic hemostatic nanofiber composites for fast clotting and minimal adhesion.

Zhe Li, Athanasios Milionis, Yu Zheng, Marcus Yee, Lukas Codispoti, Freddie Tan, Dimos Poulikakos, Choon Hwai Yap

Abstract read
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed.

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  14. Stable Air Plastron Prolongs Biofluid Repellency of Submerged Superhydrophobic Surfaces.Langmuir : the ACS journal of surfaces and colloids · 2025
    Article
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8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhe LiGuangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument, School of Biomedical Engineering, Sun Yat-Sen University, Guangzhou, 510006, China.ORCID http://orcid.org/0000-0002-1991-7930
Athanasios MilionisLaboratory of Thermodynamics in Emerging Technologies, Department of Mechanical and Process Engineering, ETH Zurich, 8092, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-0049-1255
Yu ZhengDepartment of Biomedical Engineering, National University of Singapore, Singapore, 117583, Singapore.ORCID http://orcid.org/0000-0003-3734-8839
Marcus YeeDepartment of Biomedical Engineering, National University of Singapore, Singapore, 117583, Singapore.
Lukas CodispotiLaboratory of Thermodynamics in Emerging Technologies, Department of Mechanical and Process Engineering, ETH Zurich, 8092, Zurich, Switzerland.
Freddie TanDepartment of Chemical and Biomolecular Engineering, National University of Singapore, Singapore, 117585, Singapore.ORCID http://orcid.org/0000-0002-8403-8385
Dimos PoulikakosLaboratory of Thermodynamics in Emerging Technologies, Department of Mechanical and Process Engineering, ETH Zurich, 8092, Zurich, Switzerland. dpoulikakos@ethz.ch.ORCID http://orcid.org/0000-0001-5733-6478
Choon Hwai YapDepartment of Biomedical Engineering, National University of Singapore, Singapore, 117583, Singapore. bieyapc@nus.edu.sg.ORCID http://orcid.org/0000-0003-2918-3077

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hemostatic materials are of great importance in medicine. However, their successful implementation is still challenging as it depends on two, often counteracting, attributes; achieving blood coagulation rapidly, before significant blood loss, and enabling subsequent facile wound-dressing removal, without clot tears and secondary bleeding. Here we illustrate an approach for achieving hemostasis, rationally targeting both attributes, via a superhydrophobic surface with immobilized carbon nanofibers (CNFs). We find that CNFs promote quick fibrin growth and cause rapid clotting, and due to their superhydrophobic nature they severely limit blood wetting to prevent blood loss and drastically reduce bacteria attachment. Furthermore, minimal contact between the clot and the superhydrophobic CNF surface yields an unforced clot detachment after clot shrinkage. All these important attributes are verified in vitro and in vivo with rat experiments. Our work thereby demonstrates that this strategy for designing hemostatic patch materials has great potential.

Indexed as

AnimalsBacterial AdhesionBandagesBlood CoagulationEnzyme-Linked Immunosorbent AssayFemaleFibrinHemostasisHemostaticsHumansHydrophobic and Hydrophilic InteractionsNanofibersRats, Sprague-DawleySwineFibrinHemostatics

Identifiers

PMID31804481
PMCPMC6895059

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.