ArticleNature communications2019
Comparative analysis of squamate brains unveils multi-level variation in cerebellar architecture associated with locomotor specialization.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 64 citations in OpenAlex.
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- New chromosome-scale genomes provide insights into marine adaptations of sea snakes (Hydrophis: Elapidae).BMC biology · 2023Article
- Reconstructing the origin and early evolution of the snake brain.Science advances · 2023Article
- Evolutionary origins of the prolonged extant squamate radiation.Nature communications · 2022Article
- The evolution of brain neuron numbers in amniotes.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Brain Region- and Age-Dependent 5-Hydroxymethylcytosine Activity in the Non-Human Primate.Frontiers in aging neuroscience · 2022Article
- A guide for optimal iodine staining and high-throughput diceCT scanning in snakes.Ecology and evolution · 2021Article
- Inside the head of snakes: influence of size, phylogeny, and sensory ecology on endocranium morphology.Brain structure & function · 2021Article
- Brain size variation along altitudinal gradients in the Asiatic Toad (Ecology and evolution · 2021Article
- Embryonic development of skull bones in the Sahara horned viper (Cerastes cerastes), with new insights into structures related to the basicranium and braincase roof.Journal of anatomy · 2020Article
- Cerebrotypes in Cephalopods: Brain Diversity and Its Correlation With Species Habits, Life History, and Physiological Adaptations.Frontiers in neuroanatomy · 2020Article
- Heterochronic Developmental Shifts Underlying Squamate Cerebellar Diversity Unveil the Key Features of Amniote Cerebellogenesis.Frontiers in cell and developmental biology · 2020Article
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4 authors at 1 institution in 1 country.
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Abstract
Ecomorphological studies evaluating the impact of environmental and biological factors on the brain have so far focused on morphology or size measurements, and the ecological relevance of potential multi-level variations in brain architecture remains unclear in vertebrates. Here, we exploit the extraordinary ecomorphological diversity of squamates to assess brain phenotypic diversification with respect to locomotor specialization, by integrating single-cell distribution and transcriptomic data along with geometric morphometric, phylogenetic, and volumetric analysis of high-definition 3D models. We reveal significant changes in cerebellar shape and size as well as alternative spatial layouts of cortical neurons and dynamic gene expression that all correlate with locomotor behaviours. These findings show that locomotor mode is a strong predictor of cerebellar structure and pattern, suggesting that major behavioural transitions in squamates are evolutionarily correlated with mosaic brain changes. Furthermore, our study amplifies the concept of 'cerebrotype', initially proposed for vertebrate brain proportions, towards additional shape characters.
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