Observational studyMedicine2019
Impact of number of medications and age on adherence to antihypertensive medications: A nationwide population-based study.
Observational study in Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
69 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Adherence to antihypertensives in the United States: A comparative meta-analysis of 23 million patients.Journal of clinical hypertension (Greenwich, Conn.) · 2024Pooled it
- Factors Associated with the Acceptability of Mass Drug Administration for Filariasis: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Patient adherence and response time in electronic patient-reported outcomes: insights from three longitudinal clinical trials.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024Trial
- Independent and joint associations of fatty liver index and physical activity with mortality in adults with hypertension: a nationwide cohort study.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Medication adherence and associated factors in patients with chronic hepatitis B in Zhejiang Province, Eastern China.BMC public health · 2026Article
- Associations between social determinants and poor hypertension treatment adherence among middle-aged and older people in rural China: a hospital-based case‒control study.BMC public health · 2026Article
- Antihypertensive medication adherence and associated risk factors among adults with hypertension: a cross-sectional study in a teaching hospital, Ghana.BMC cardiovascular disorders · 2026Article
- Age-related risk factors for leftover drugs: a lifespan analysis in community pharmacies.Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques · 2026Observational
- Medication Regimen Complexity and Patient-Reported Adherence: A Cross-Sectional Study in Internal Medicine Outpatients.Patient preference and adherence · 2026Article
- Association of physical activity with risk of major adverse cardiovascular events and mortality in Korean adults with hypertension.Clinical hypertension · 2026Article
- Cross-Sectional Study on Factors Associated with Hyperpolypharmacy and Medication Adherence in Older Adults with Multimorbidity and Polypharmacy.Drugs & aging · 2026Article
- A long shot? Affective temperaments predict adherence to pharmacotherapy during infertility treatment in a prospective longitudinal study.Dialogues in clinical neuroscience · 2025Article
- Contacts to general practitioners and renewal of antihypertensive medication - a four-year follow-up in primary health care, Turku, Finland.BMC primary care · 2025Article
- Women's adherence to medication and hope in the presence of another chronic disease besides breast cancer: a cross-sectional study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Examining the relationship between adherence and the number of cardiometabolic medications: Findings for patients with type 2 diabetes within a Tribal health care system.Journal of managed care & specialty pharmacy · 2025Article
- Perceived HBV-Related Stigma Is Associated With Lower Antiviral Medication Adherence in Patients With Chronic Hepatitis B.Journal of viral hepatitis · 2025Article
- Article
- Patterns of adherence to home blood pressure monitoring among men and women in the Electronic Framingham Heart Study.PloS one · 2025Article
- Is Satisfaction with the Medication Provisions of the Senior Citizens Act and Frequency of Senior Identification Card Use Associated with Medication Compliance among Hypertensive Patients in the Philippines?Acta medica Philippina · 2025Article
- Implementation of an adherence pharmacy referral protocol for patients taking sacubitril/valsartan.Journal of managed care & specialty pharmacy · 2025Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study tried to investigate the effects of number of medications and age on antihypertensive medication adherence in a real-world setting using a nationwide representative cohort.We obtained data from the National Health Insurance Service-National Sample Cohort (NHIS-NSC) of Korea, which is a sample of 2.2% (N = 1,048,061) of total population (N = 46,605,433). Patients aged 20 years or older (N = 150,550) who took antihypertensive medications for at least 1 year were selected. Medication possession ratio (MPR) was used for measuring adherence. The subjects were divided into 5 subgroups according to total number of medications: 1-2, 3-4, 5-6, 7-8, and 9 or more. The mean age and the mean number of medications were 60.3 ± 12.6 years and 4.1 ± 2.2, respectively. The mean MPR was 80.4 ± 23.9%, and 66.9% (N = 100,645) of total subjects were adherent (MPR ≥ 80%). The overall tendency of antihypertensive medication adherence according to the total number of medications displayed an inverted U-shape with a peak at 3-4 drugs. Adherence consistently increased as the age increased until age 69 and started to decrease from age 70. The proportion of adherent patients (MPR ≥ 80%) according to the total number of medications also showed an inverted U-shape with a peak at 3-4 drugs. When the same number of drugs was taken, the proportion of adherent patients according to age featured an inverted U- shape with a peak at 60 to 69 years. Patients taking 9 or more total drugs had the overall odds ratio (95% CI) of non-adherence (MPR < 80%) with 1.17 (1.11-1.24) compared with those taking 1 to 8 total drugs and the odds ratios in the age subgroups of 40 to 49, 50 to 59, 60 to 69 years were 1.57 (1.31-1.87), 1.21 (1.08-1.36), and 1.14 (1.04-1.25), respectively (P < .05).Association between age, total number of medications, and antihypertensive adherence displayed an inverted U-shape with a peak at 3 to 4 total medications and at age 60 to 69 years. When the total number of drugs was 9 or more, adherence decreased prominently, regardless of age.
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