ArticleThe British journal of radiology2020
Photons or protons for reirradiation in (non-)small cell lung cancer: Results of the multicentric ROCOCO
Article in The British journal of radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- American Radium Society Appropriate Use Criteria Systematic Review and Guidelines on Reirradiation for Non-Small Cell Lung Cancer Executive Summary.International journal of radiation oncology, biology, physics · 2025Guideline
- Modeling Time-Dependent Recovery to Improve Esophagitis Prediction in Thoracic Reirradiation.International journal of radiation oncology, biology, physics · 2026Article
- Re-evaluating previous dose and allowing increasing recovery (REPAIR): study protocol for a thoracic reirradiation phase I dose escalation trial.BMC cancer · 2026Article
- Cumulative oesophageal dose and risk of high-grade toxicity in thoracic re-irradiation: a dose/toxicity analysis.Clinical and translational radiation oncology · 2026Review
- Thoracic reirradiation clinical and technical practices: a survey from the reirradiation Collaborative Group (ReCOG).Clinical and translational radiation oncology · 2026Article
- Feasibility and efficacy of hypofractionated proton reirradiation for recurrent lung cancer.International journal of particle therapy · 2025Article
- Improving reirradiation of recurrent non-small cell lung cancer through non-coplanar beam arrangements.Physics and imaging in radiation oncology · 2025Article
- Reirradiation - still navigating uncharted waters?Clinical and translational radiation oncology · 2024Review
- High Dose Thoracic Re-Irradiation and Chemo-Immunotherapy for Centrally Recurrent NSCLC.Cancers · 2022Review
- Thoracic radiotherapy in small cell lung cancer-a narrative review.Translational lung cancer research · 2021Review
- Proton Reirradiation: Expert Recommendations for Reducing Toxicities and Offering New Chances of Cure in Patients With Challenging Recurrence Malignancies.Seminars in radiation oncology · 2020Review
- Clinical outcomes and toxicity predictors of thoracic re-irradiation for locoregionally recurrent lung cancer.Clinical and translational radiation oncology · 2020Article
- Proton therapy special feature: introductory editorial.The British journal of radiology · 2020Article
- Reirradiation: Standards, challenges, and patient-focused strategies across tumor types.CA: a cancer journal for cliniciansReview
- An International Expert Survey on the Indications and Practice of Radical Thoracic Reirradiation for Non-Small Cell Lung Cancer.Advances in radiation oncologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 9 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveLocally recurrent disease is of increasing concern in (non-)small cell lung cancer [(N)SCLC] patients. Local reirradiation with photons or particles may be of benefit to these patients. In this multicentre in
methods24 consecutive patients with a second primary (N)SCLC or recurrent disease after curative-intent, standard fractionated radio(chemo)therapy were included in this study. The target volumes and OARs were centrally contoured and distributed to the participating ROCOCO sites. Remaining doses to the OARs were calculated on an individual patient's basis. Treatment planning was performed by the participating site using the clinical treatment planning system and associated beam characteristics.
resultsTreatment plans for all modalities (five photon and two proton plans per patient) were available for 22 patients (
conclusionHighly conformal photon and proton beam techniques enable high-dose reirradiation of the target volume. They, however, significantly differ in the dose deposited in the OARs. The therapeutic options, ADVANCES IN KNOWLEDGE: Highly conformal photon and proton beam techniques enable high-dose reirradiation of the target volume. In light of the abilities of the various highly conformal techniques to spare specific OARs, the therapeutic options need to be carefully weighed and patients included in the decision-making process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.