ReviewJournal of abnormal psychology2020
Redefining phenotypes to advance psychiatric genetics: Implications from hierarchical taxonomy of psychopathology.
Review in Journal of abnormal psychology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 1 of them a synthesis that pooled it.
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Who cites it
56 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The hierarchical taxonomy of psychopathology and the search for neurobiological substrates of mental illness: A systematic review and roadmap for future research.Journal of psychopathology and clinical science · 2024Pooled it
- Common and Unique Etiological Influences on Personality and Personality Disorders in Youth.Psychopathology · 2026Article
- Dissecting the polygenic architecture of psychopathology via singular value decomposition of eight psychiatric genome-wide association studies and evaluation of component-based polygenic scores.General psychiatry · 2026Article
- Internalizing Psychiatric Symptoms in People With Mosaicism for Trisomy 21.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2025Article
- Passive Smartphone Sensors for Detecting Psychopathology.JAMA network open · 2025Article
- Integrating HiTOP and RDoC frameworks part II: shared and distinct biological mechanisms of externalizing and internalizing psychopathology.Psychological medicine · 2025Article
- Integrating HiTOP and RDoC frameworks Part I: Genetic architecture of externalizing and internalizing psychopathology.Psychological medicine · 2025Article
- Heritability and polygenic load for comorbid anxiety and depression.Translational psychiatry · 2025Article
- New diagnosis in psychiatry: beyond heuristics.Psychological medicine · 2025Review
- Leveraging pleiotropy for the improved treatment of psychiatric disorders.Molecular psychiatry · 2025Review
- Associations of polygenic scores and developmental trajectories of externalizing behaviors.Development and psychopathology · 2025Article
- Neurobiology of attention-deficit hyperactivity disorder: historical challenges and emerging frontiers.Nature reviews. Neuroscience · 2024Review
- An Honest Reckoning With the Amygdala and Mental Illness.The American journal of psychiatry · 2024Review
- Age-Related Variations of Genetic and Environmental Contributions to the Covariation of Fear, Distress and Externalizing Symptoms: A Twin Study in Childhood and Adolescence.Child psychiatry and human development · 2024Article
- Exploring the genetic etiology across the continuum of the general psychopathology factor: a Swedish population-based family and twin study.Molecular psychiatry · 2024Article
- Examining the role of personality functioning in a hierarchical taxonomy of psychopathology using two years of ambulatory assessed data.Translational psychiatry · 2024Article
- Mapping potential pathways from polygenic liability through brain structure to psychological problems across the transition to adolescence.Journal of child psychology and psychiatry, and allied disciplines · 2024Article
- Using Alternative Definitions of Controls to Increase Statistical Power in GWAS.Behavior genetics · 2024Article
- Internalizing Psychiatric Symptoms in People with Mosaicism for Trisomy 21.medRxiv : the preprint server for health sciences · 2024Article
- A Multivariate Genome-Wide Association Study Reveals Neural Correlates and Common Biological Mechanisms of Psychopathology Spectra.Research square · 2024Article
Corrections and comments
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33 authors.
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Abstract
Genetic discovery in psychiatry and clinical psychology is hindered by suboptimal phenotypic definitions. We argue that the hierarchical, dimensional, and data-driven classification system proposed by the Hierarchical Taxonomy of Psychopathology (HiTOP) consortium provides a more effective approach to identifying genes that underlie mental disorders, and to studying psychiatric etiology, than current diagnostic categories. Specifically, genes are expected to operate at different levels of the HiTOP hierarchy, with some highly pleiotropic genes influencing higher order psychopathology (e.g., the general factor), whereas other genes conferring more specific risk for individual spectra (e.g., internalizing), subfactors (e.g., fear disorders), or narrow symptoms (e.g., mood instability). We propose that the HiTOP model aligns well with the current understanding of the higher order genetic structure of psychopathology that has emerged from a large body of family and twin studies. We also discuss the convergence between the HiTOP model and findings from recent molecular studies of psychopathology indicating broad genetic pleiotropy, such as cross-disorder SNP-based shared genetic covariance and polygenic risk scores, and we highlight molecular genetic studies that have successfully redefined phenotypes to enhance precision and statistical power. Finally, we suggest how to integrate a HiTOP approach into future molecular genetic research, including quantitative and hierarchical assessment tools for future data-collection and recommendations concerning phenotypic analyses. (PsycINFO Database Record (c) 2020 APA, all rights reserved).
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