Trial reportChemical research in toxicology2020
Investigating E-Cigarette Particle Emissions and Human Airway Depositions under Various E-Cigarette-Use Conditions.
Trial report in Chemical research in toxicology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- The triple-hit hypothesis: exploring pulmonary e-cigarette, PMEuropean respiratory review : an official journal of the European Respiratory Society · 2026Review
- Effects of E-Liquid Formulations on Nicotine Vapor Pressure and Implications for Nicotine Delivery and Toxicity.Toxics · 2026Article
- The respiratory epithelium in the era of vaping: insights fromEuropean respiratory review : an official journal of the European Respiratory Society · 2025Review
- A comparative toxicological evaluation of emerging nicotine analogs 6-methyl nicotine and nicotinamide: a scoping review.Archives of toxicology · 2025Article
- Physical and Chemical Characterization of Aerosols Produced from Commercial Nicotine Salt-Based E-Liquids.Chemical research in toxicology · 2025Article
- Multi-Omics Assessment of Puff Volume-Mediated Salivary Biomarkers of Metal Exposure and Oxidative Injury Associated with Electronic Nicotine Delivery Systems.Environmental health perspectives · 2025Article
- Evaluation of carbonyl collection methods in electronic cigarette aerosols.Frontiers in chemistry · 2025Article
- Ventilation and features of the lung environment dynamically alter modeled intrapulmonary aerosol exposure from inhaled electronic cigarettes.Scientific reports · 2024Article
- The role of puff volume in vaping emissions, inhalation risks, and metabolic perturbations: a pilot study.Scientific reports · 2024Article
- Flow Rate and Wall Shear Stress Characterization of a Biomimetic Aerosol Exposure System.Journal of biomechanical engineering · 2024Article
- Optical characterization of native aerosols from e-cigarettes in localized volumes.Biomedical optics express · 2024Article
- Effects of Device Settings and E-Liquid Characteristics on Mouth-Throat Losses of Nicotine Delivered with Electronic Nicotine Delivery Systems (ENDS).Journal of aerosol science · 2023Article
- Toxicological Assessment of Particulate and Metal Hazards Associated with Vaping Frequency and Device Age.Toxics · 2023Article
- Understanding the influence of atomizing power on electronic cigarette aerosol size and inhalation dose estimation.Aerosol science and technology : the journal of the American Association for Aerosol Research · 2023Article
- The Ultra fit community mask-Toward maximal respiratory protection via personalized face fit.PloS one · 2023Article
- Transfer of Metals to the Aerosol Generated by an Electronic Cigarette: Influence of Number of Puffs and Power.International journal of environmental research and public health · 2022Article
- Formation of Redox-Active Duroquinone from Vaping of Vitamin E Acetate Contributes to Oxidative Lung Injury.Chemical research in toxicology · 2022Article
- Assessing variability of aerosols generated from e-Cigarettes.Inhalation toxicology · 2022Article
- E-cigarette aerosol collection using converging and straight tubing Sections: Physical mechanisms.Journal of colloid and interface science · 2021Article
- Effect of Puffing Behavior on Particle Size Distributions and Respiratory Depositions From Pod-Style Electronic Cigarette, or Vaping, Products.Frontiers in public health · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
E-cigarette use is dramatically increasing, particularly with adolescents. While the chemical composition of e-liquids and e-vapor is well characterized, the particle size distribution and the human airways deposition patterns of e-cigarette particles are understudied and poorly understood despite their likely contribution to adverse health effects from e-cigarette usage. In this study, we examined the impacts of e-cigarette device power, e-liquid composition, and vaping topography on e-cigarette particle sizes and their deposition in human airways. In addition, we observed that particle measurement conditions (dilution ratio, temperature, and humidity) significantly affect measured e-cigarette particle sizes. E-cigarette power output significantly increased particle count median diameters (CMD) from 174 ± 13 (particles generated under 6.4 W) to 236 ± 14 nm (particles generated under 31.1 W). E-cigarette particles generated from propylene glycol-based e-liquids (CMD = 145 ± 8 nm and mass median diameter [MMD] = 3.06 ± 0.17 μm) were smaller than those generated from vegetable glycerin-based e-liquids (CMD = 182 ± 9 nm and MMD = 3.37 ± 0.21 μm). Puff volume also impacted vapor particle size: CMD and MMD were 154 ± 11 nm and 3.50 ± 0.27 μm, 163 ± 6 nm and 3.35 ± 0.24 μm, and 146 ± 12 nm and 2.95 ± 0.14 μm, respectively, for 35, 90, and 170 mL puffs. Estimated e-cigarette particle mass deposition fractions in tracheobronchial and bronchoalveolar regions were 0.504-0.541 and 0.073-0.306, respectively. Interestingly, e-cigarette particles are smaller than the particles generated from cigarette smoking but have similar human airway deposition patterns.
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Registered trials
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