ArticleObesity (Silver Spring, Md.)2020
Changes in Proteomic Profiles are Related to Changes in BMI and Fat Distribution During 10 Years of Aging.
Article in Obesity (Silver Spring, Md.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Proteomic Insights into Childhood Obesity: A Systematic Review of Protein Biomarkers and Advances.International journal of molecular sciences · 2025Pooled it
- Review
- Proteomic associations with fluctuation and long-term changes in BMI: A 40-year follow-up study.Diabetes, obesity & metabolism · 2025Article
- The Effects of Concurrent Training on Molecular, Functional, and Clinical Outcomes in Breast Cancer Survivors: A Pilot Study.Cancers · 2025Article
- Proteomic associations with fluctuation and long-term changes in BMI: A 40-year follow-up study.medRxiv : the preprint server for health sciences · 2025Article
- Exploring the Genetic Basis of Ketosis: Preliminary GWAS Findings on Beta-Hydroxybutyrate Levels in Holstein Cattle.International journal of genomics · 2025Article
- Revealing brain cell-stratified causality through dissecting causal variants according to their cell-type-specific effects on gene expression.Nature communications · 2024Article
- Longitudinal multi-omics study reveals common etiology underlying association between plasma proteome and BMI trajectories in adolescent and young adult twins.BMC medicine · 2023Article
- Evaluation of circulating plasma proteins in breast cancer using Mendelian randomisation.Nature communications · 2023Article
- Comprehensive analyses of circulating cardiometabolic proteins and objective measures of fat mass.International journal of obesity (2005) · 2023Article
- Longitudinal multi-omics study reveals common etiology underlying association between plasma proteome and BMI trajectories in adolescent and young adult twins.medRxiv : the preprint server for health sciences · 2023Article
- Proteomic Profiles of Body Mass Index and Waist-to-Hip Ratio and Their Role in Incidence of Diabetes.The Journal of clinical endocrinology and metabolism · 2022Article
- In-Depth Analysis of the Hidradenitis Suppurativa Serum Proteome Identifies Distinct Inflammatory Subtypes.The Journal of investigative dermatology · 2021Article
- Proteomic profiling of low muscle and high fat mass: a machine learning approach in the KORA S4/FF4 study.Journal of cachexia, sarcopenia and muscle · 2021Article
- Inflammation-related plasma protein levels and association with adiposity measurements in young adults.Scientific reports · 2021Article
- Abnormalities of Serum Fatty Acids in Children With Henoch-Schönlein Purpura by GC-MS Analysis.Frontiers in pediatrics · 2020Article
- Effects of Age on Inflammatory Profiles and Nutrition/Energy Metabolism in Domestic Cats.Veterinary medicine (Auckland, N.Z.) · 2020Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveThis study investigated how changes in 84 proteins over a 10-year period of aging were related to changes in measures of body fat and distribution over the same period.
methodsCardiovascular candidate proteins were measured using the proximal extension assay technique, along with BMI and waist-hip ratio (WHR), at ages 70, 75, and 80 in 1,016 participants of the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) cohort. Associations of changes in plasma protein levels, BMI, and WHR over time were analyzed using linear mixed models.
resultsChanges in 19 and 16 proteins were significantly associated with changes in BMI and WHR, respectively (P < 0.00059), over the investigated 10-year period. Leptin and fatty acid-binding protein 4 were among the proteins most strongly associated with changes in both BMI and WHR. Four of the proteins significantly tracked with change in BMI (P < 0.00059) but not WHR (P > 0.05): endothelial cell-specific molecule 1, pentraxin-related protein PTX3, ST2 protein (also known as interleukin-1 receptor-like 1), and spondin-1. Five proteins tracked with change in WHR (P < 0.00059) but not BMI (P > 0.05): caspase-8, cathepsin L1, oxidized low-density lipoprotein receptor 1, interleukin-6 receptor subunit alpha, and C-C motif chemokine 20.
conclusionsThis is the first large longitudinal study of how changes in plasma protein signatures are associated with changes in measures of body fat and distribution over 10 years of aging.
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Registered trials
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