ArticleThe European journal of neuroscience2020
Activity in orbitofrontal neuronal ensembles reflects inhibitory control.
Article in The European journal of neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed.
- Electrophysiological features of signals recorded from white matter.bioRxiv : the preprint server for biology · 2026Article
- Parietal cortex is recruited by frontal and cingulate areas to support action monitoring and updating during stopping.NeuroImage · 2025Article
- Whether or not to act is determined by distinct signals from motor thalamus and orbitofrontal cortex to secondary motor cortex.Nature communications · 2025Article
- Article
- Utilizing maternal prenatal cognition as a predictor of newborn brain measures of intellectual development.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2024Article
- Role of Orbitofrontal Cortex and Differential Effects of Acute and Chronic Stress on Motor Impulsivity Measured With 1-Choice Serial Reaction Time Test in Male Rats.The international journal of neuropsychopharmacology · 2022Article
- The effects of early life stress on impulsivity.Neuroscience and biobehavioral reviews · 2022Review
- Convergent and Divergent Structural Connectivity of Brain White Matter Network Between Patients With Erectile Dysfunction and Premature Ejaculation: A Graph Theory Analysis Study.Frontiers in neurology · 2022Article
- Reactive and Proactive Adaptation of Cognitive and Motor Neural Signals during Performance of a Stop-Change Task.Brain sciences · 2021Review
- The ever-changing OFC landscape: What neural signals in OFC can tell us about inhibitory control.Behavioral neuroscience · 2021Review
- Anterior cingulate cortex is necessary for adaptation of action plans.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
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Authors and funding
3 authors.
Funding
Abstract
Stopping, or inhibition, is a form of self-control that is a core element of flexible and adaptive behavior. Its neural origins remain unclear. Some views hold that inhibition decisions reflect the aggregation of widespread and diverse pieces of information, including information arising in ostensible core reward regions (i.e., outside the canonical executive system). We recorded activity of single neurons in the orbitofrontal cortex (OFC) of macaques, a region associated with economic decisions, and whose role in inhibition is debated. Subjects performed a classic inhibition task known as the stop signal task. Ensemble decoding analyses reveal a clear firing rate pattern that distinguishes successful from failed inhibition and that begins after the stop signal and before the stop signal reaction time (SSRT). We also found a different and orthogonal ensemble pattern that distinguishes successful from failed stopping before the beginning of the trial. These signals were distinct from, and orthogonal to, value encoding, which was also observed in these neurons. The timing of the early and late signals was, respectively, consistent with the idea that neuronal activity in OFC encodes inhibition both proactively and reactively.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.