Evidence map›Paper›PMID 31803824›Full record

ArticleAdvanced materials technologies2018

Stereolithography for Personalized Left Atrial Appendage Occluders.

Sanlin S Robinson, Cameron A Aubin, Thomas J Wallin, Saleh Gharaie, Patricia A Xu, Kaiyang Wang, Simon N Dunham, Bobak Mosadegh, Robert F Shepherd

Open access · bronzeAbstract read
In one paragraph

Article in Advanced materials technologies, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Sanlin S RobinsonDepartment of Materials Science and Engineering, Cornell University, Ithaca, NY 14853, USA.
Cameron A AubinSibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY 14853, USA.
Thomas J WallinDepartment of Materials Science and Engineering, Cornell University, Ithaca, NY 14853, USA.
Saleh GharaieDalio Institute of Cardiovascular Imaging, Department of Radiology, New York-Presbyterian, Hospital and Weill Cornell Medicine, New York, NY 10021, USA.
Patricia A XuSibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY 14853, USA.
Kaiyang WangDepartment of Materials Science and Engineering, Cornell University, Ithaca, NY 14853, USA.
Simon N DunhamDalio Institute of Cardiovascular Imaging, Department of Radiology, New York-Presbyterian, Hospital and Weill Cornell Medicine, New York, NY 10021, USA.
Bobak MosadeghDalio Institute of Cardiovascular Imaging, Department of Radiology, New York-Presbyterian, Hospital and Weill Cornell Medicine, New York, NY 10021, USA.
Robert F ShepherdDepartment of Materials Science and Engineering, Cornell University, Ithaca, NY 14853, USA.
Cornell University · USNewYork–Presbyterian Hospital · US

Funding

J. NRSA Training CoreTL1TR002386 · NCATS · WEILL MEDICAL COLL OF CORNELL UNIV · PI Genevieve Giny Fouda Amou ou · 2017 to 2026
$5.8M
NCATS NIH HHS TL1 TR002386
6 · The paper itself

Abstract

Advancements in 3D additive manufacturing have spurred the development of effective patient-specific medical devices. Prior applications are limited to hard materials, however, with few implementations of soft devices that better match the properties of natural tissue. This paper introduces a rapid, low cost, and scalable process for fabricating soft, personalized medical implants via stereolithography of elastomeric polyurethane resin. The effectiveness of this approach is demonstrated by designing and manufacturing patient-specific endocardial implants. These devices occlude the left atrial appendage, a complex structure within the heart prone to blood clot formation in patients with atrial fibrillation. Existing occluders permit residual blood flow and can damage neighboring tissues. Here, the robust mechanical properties of the hollow, printed geometries are characterized and stable device anchoring through in vitro benchtop testing is confirmed. The soft, patient-specific devices outperform non-patient-specific devices in embolism and occlusion experiments, as well as in computational fluid dynamics simulations.

Indexed as

3D printingelastomersmedical devicespatient-specificstereolithography

Identifiers

PMID31803824
PMCPMC6892588
OpenAlexW2893507274

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.