Evidence map›Paper›PMID 31803793›Full record

ArticleBio-protocol2019

Antisense Oligodeoxynucleotide Perfusion Blocks Gene Expression of Synaptic Plasticity-related Proteins without Inducing Compensation in Hippocampal Slices.

Panayiotis Tsokas, Bruno Rivard, Changchi Hsieh, James E Cottrell, André Antonio Fenton, Todd Charlton Sacktor

Open access · bronzeAbstract read
In one paragraph

Article in Bio-protocol, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Resveratrol Preconditioning Protects Against Ischemia-Induced Synaptic Dysfunction and Cofilin Hyperactivation in the Mouse Hippocampal Slice.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Panayiotis TsokasDepartment of Physiology and Pharmacology, The Robert F. Furchgott Center for Neural and Behavioral Science, State University of New York Downstate Medical Center, Brooklyn, United States.
Bruno RivardDepartment of Physiology and Pharmacology, The Robert F. Furchgott Center for Neural and Behavioral Science, State University of New York Downstate Medical Center, Brooklyn, United States.
Changchi HsiehDepartment of Physiology and Pharmacology, The Robert F. Furchgott Center for Neural and Behavioral Science, State University of New York Downstate Medical Center, Brooklyn, United States.
James E CottrellDepartment of Anesthesiology, State University of New York Downstate Medical Center, Brooklyn, United States.
André Antonio FentonDepartment of Physiology and Pharmacology, The Robert F. Furchgott Center for Neural and Behavioral Science, State University of New York Downstate Medical Center, Brooklyn, United States.
Todd Charlton SacktorDepartment of Physiology and Pharmacology, The Robert F. Furchgott Center for Neural and Behavioral Science, State University of New York Downstate Medical Center, Brooklyn, United States.
SUNY Downstate Health Sciences University · USState University of New York · US

Funding

PROTEIN KINASE C ISOZYMES IN HIPPOCAMPAL PLASTICITYR01MH053576 · NIMH · SUNY DOWNSTATE MEDICAL CENTER · PI SACKTOR, TODD C · 2000 to 2014
$4.9M
Molecular mechanisms of memory maintenance and dysfunction in neural circuitsR01MH115304 · NIMH · SUNY DOWNSTATE MEDICAL CENTER · PI FENTON, ANDRE ANTONIO, SACKTOR, TODD C · 2018 to 2022
$4.1M
Regulation and Neural Function of Atypical PKCR37MH057068 · NIMH · SUNY DOWNSTATE MEDICAL CENTER · PI SACKTOR, TODD C · 2011 to 2020
$4.0M
Translation, Synchrony, and CognitionR01MH099128 · NIMH · NEW YORK UNIVERSITY · PI FENTON, ANDRE ANTONIO · 2013 to 2017
$2.0M
CRCNS: PKMzeta-Dependent Protein Synthesis Maintains Synaptic PlasticityR01DA034970 · NIDA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI SHOUVAL, HAREL ZEEV · 2012 to 2016
$1.4M
Experience-dependent Modulation of Synaptic Circuits in the HippocampusR21NS091830 · NINDS · SUNY DOWNSTATE MEDICAL CENTER · PI ALARCON, JUAN MARCOS · 2015 to 2016
$456k
NIDA NIH HHS R01 DA034970NIMH NIH HHS R01 MH053576NIMH NIH HHS R01 MH099128NIMH NIH HHS R01 MH115304NIMH NIH HHS R37 MH057068NINDS NIH HHS R21 NS091830
6 · The paper itself

Abstract

The elucidation of the molecular mechanisms of long-term synaptic plasticity has been hindered by both the compensation that can occur after chronic loss of the core plasticity molecules and by

Indexed as

Long-Term PotentiationLTPPiezoelectric micropumpPKM-ζPKMζZIP

Identifiers

PMID31803793
PMCPMC6892586
OpenAlexW2977870814

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.