Evidence map›Paper›PMID 31803789›Full record

ReviewOrthopaedic journal of sports medicine2019

Defining Components of Early Functional Rehabilitation for Acute Achilles Tendon Rupture: A Systematic Review.

Jennifer A Zellers, Marianne Christensen, Inge Lunding Kjær, Michael Skovdal Rathleff, Karin Grävare Silbernagel

Open access · goldAbstract readReview
In one paragraph

Review in Orthopaedic journal of sports medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
  5. Article
  6. A Novel Measurement of Altered Achilles Subtendon Load Sharing 6-12 Months Following Rupture.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026
    Article
  7. Review
  8. Muscle Contraction Is Essential for Tendon Healing and Muscle Function Recovery After Achilles Tendon Rupture and Surgical Repair.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Focal adhesion kinase regulates tendon cell mechanoresponse and physiological tendon development.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
    Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. A novel murine muscle loading model to investigate Achilles musculotendinous adaptation.Journal of applied physiology (Bethesda, Md. : 1985) · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Jennifer A ZellersProgram in Physical Therapy, Washington University School of Medicine in St Louis, St Louis, Missouri, USA.
Marianne ChristensenPhysiotherapy and Occupational Therapy, Aalborg University Hospital, Aalborg, Denmark.
Inge Lunding KjærOrthopaedic Research Unit, Aalborg University Hospital, Aalborg, Denmark.
Michael Skovdal RathleffPhysiotherapy and Occupational Therapy, Aalborg University Hospital, Aalborg, Denmark.
Karin Grävare SilbernagelDepartment of Physical Therapy, University of Delaware, Newark, Delaware, USA.
Aalborg University Hospital · DKAalborg University · DKUniversity of Delaware · USWashington University in St. Louis · US

Funding

DOCTORAL TRAINING PROGRAM IN MOVEMENT SCIENCET32HD007434 · NICHD · WASHINGTON UNIVERSITY · PI Michael D Harris, Catherine Lang · 1993 to 2026
$4.2M
Recovery of symptoms, function, tendon structure and mechanical properties in patients with Achilles Tendinopathy: A comparison between men and womenR01AR072034 · NIAMS · UNIVERSITY OF DELAWARE · PI GRAVARE SILBERNAGEL, KARIN M E · 2018 to 2022
$2.5M
NIAMS NIH HHS R01 AR072034NICHD NIH HHS T32 HD007434
6 · The paper itself

Abstract

backgroundEarly functional rehabilitation is frequently discussed in treating Achilles tendon rupture. A consistent definition of what constitutes early functional rehabilitation has not been established across the literature, despite studies supporting its efficacy. A standardized definition would be helpful to pool data across studies, allow for between-study comparisons, and ultimately work toward developing clinical guidelines. PURPOSE: To define early functional rehabilitation (including when it is initiated and what it entails) when used to treat Achilles tendon rupture and to identify outcome measures for evaluating the effect of treatment. STUDY

designSystematic review; Level of evidence, 4.

methodsOvid MEDLINE, EMBASE, PEDro, CINAHL, and Cochrane databases were searched for relevant studies. Eligibility criteria for selecting studies consisted of randomized controlled trials, cohort studies, and case series (≥10 participants) including weightbearing or exercise-based interventions within 8 weeks after Achilles tendon rupture.

resultsA total of 174 studies published between 1979 and 2018 were included. Studies were rated a median (interquartile range [IQR]) of 17 (15-20) on the Downs & Black checklist and included 9098 participants. Early functional rehabilitation incorporated weightbearing (95%), range of motion (73%), and isometric/strengthening exercises (50%). Weightbearing was initiated within the first week, whereas exercise (eg, ankle range of motion, strengthening, whole-body conditioning) was initiated in the second week. Initiation of exercises varied based on whether treatment was nonsurgical (mean, 3.0 weeks; IQR, 2.0-4.0 weeks) or simple (mean, 2.0 weeks; IQR, 0.0-2.3 weeks) or augmented surgical repair (mean, 0.5 weeks; IQR, 0.0-2.8 weeks) (

conclusionEarly functional rehabilitation includes weightbearing and a variety of exercise-based interventions initiated within the first 2 weeks after acute Achilles tendon rupture/repair. Because early functional rehabilitation has lacked a standardized definition, interventions and outcome measures are highly variable, and pooling data across studies should be done with attention paid to what was included in the intervention and how treatment was assessed.

Indexed as

Achillesanklemobilizationoutcomesweightbearing

Identifiers

PMID31803789
PMCPMC6878623
OpenAlexW2989721456

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.