Evidence map›Paper›PMID 31803643›Full record

ReviewJournal of family medicine and primary care2019

The role of gut microbiome in the pathogenesis of psoriasis and the therapeutic effects of probiotics.

Dalal I Alesa, Haidar M Alshamrani, Yahya A Alzahrani, Dania N Alamssi, Nada S Alzahrani, Marwan E Almohammadi

RetractedOpen access · goldAbstract readReviewRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of family medicine and primary care, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 62 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Microbiology spectrum · 2024
    Observational
  9. Review
  10. Review
  11. Article
  12. A bibliometrics study on the status quo and hot topics of pathogenesis of psoriasis based on Web of Science.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024
    Article
  13. Review
  14. Review
  15. The Role of Yeasts in Human Health: A Review.Life (Basel, Switzerland) · 2023
    Review
  16. Review
  17. Article
  18. Review
  19. Article
  20. Psoriatic arthritis from a mechanistic perspective.Nature reviews. Rheumatology · 2022
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Dalal I AlesaDermatology Resident, Alnoor Specialist Hospital, Makkah, Saudi Arabia.
Haidar M AlshamraniFaculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.
Yahya A AlzahraniFaculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Dania N AlamssiGeneral Practitioner, Consultant Center for Dermatology and Venereology Clinics, Makkah, Saudi Arabia.
Nada S AlzahraniFaculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.
Marwan E AlmohammadiFaculty of Medicine, Albaha University, Albaha, Saudi Arabia.
King Abdulaziz University · SAUmm al-Qura University · SAAl Baha University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The adult intestine hosts a huge number of diverse bacterial species, collectively referred to as the microbiome, that reside mainly in the lower gut, where they maintain a symbiotic relationship with their host. Recent research points to a central role of the microbiome in many biological processes. These microbial communities are influenced by multiple environmental and dietary factors and can modulate immune responses. In addition to local effects on the gastrointestinal tract, the microbiota is associated with effects on other organs and tissues, such as the skin. Indeed, an altered microbiome has been associated with skin disorders in several instances. Thus, in this review, we describe the recent advances regarding the interplay between gut microbiota and the skin. We explore how this potential link affects skin homeostasis and its influence on modulating the cutaneous immune response, focusing on psoriasis disorder. Finally, we discuss how to take advantage of this interplay to manage this disorder, particularly through probiotics administration. In the gastrointestinal tract, the microbiome has been proven to be important in the maintenance of the balance between effector T cells and regulatory T cells, and the induction of immunoglobulin A. Moreover, gut bacterial dysbiosis is associated with chronic inflammatory disorders of the skin, such as psoriasis. Thus, the microbiome can be considered an effective therapeutical target for treating this disorder. Despite some limitations, interventions with probiotics seem promising for the development of a preventive therapy by restoring altered microbiome functionality or as an adjuvant in specific immunotherapy.

Indexed as

Autoimmune diseasecytokineinflammationregulatory T cellsshort-chain fatty aciduLactobacillus

Identifiers

PMID31803643
PMCPMC6881942
OpenAlexW2988761627

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.