ReviewJournal of family medicine and primary care2019
Metabolic syndrome and periodontal disease: An overview for physicians.
Review in Journal of family medicine and primary care, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effect ofCurrent medicinal chemistry · 2025Pooled it
- Association between smoking and periodontitis severity in patients attending a periodontology clinic: a cross-sectional study.BMC oral health · 2026Article
- Molecular cytokine-dependent mechanisms of periodontitis pathogenesis and the potential for pharmacological IL-1 modulation in disease treatment.Frontiers in dental medicine · 2026Review
- Patient Awareness and Recognition of Early Signs of Periodontitis in the Northwestern Romanian Population: A Cross-Sectional Questionnaire-Based Study on 518 Adults.Healthcare (Basel, Switzerland) · 2025Article
- Deep learning for automated dental plaque index assessment: validation against expert evaluations.BMC oral health · 2025Article
- Epidemiological trends and incidence prediction of periodontal disease based on the Global Burden of Disease study 2021.Frontiers in dental medicine · 2025Article
- Periodontal disease and serum uric acid levels in the absence of metabolic syndrome: is there a link? A study on a sample of Cameroonian adults.BMC oral health · 2024Article
- The Associations of Dental and Periodontal Lesions with the Microvascular Complications in Patients with Type 2 Diabetes Mellitus: A Case-Control Study.Life (Basel, Switzerland) · 2024Article
- GPR40/GPR120 Agonist GW9508 Improves Metabolic Syndrome-Exacerbated Periodontitis in Mice.International journal of molecular sciences · 2024Article
- Cinnamaldehyde Protects againstInternational journal of molecular sciences · 2024Article
- Higher Prevalence of the Periodontal PathogenPathogens (Basel, Switzerland) · 2024Article
- Prevalence of metabolic syndrome and its association with oral health: First results from the Kurdish cohort study.Health science reports · 2023Article
- Serum C reactive protein and procalcitonin are valuable predictors of coronary heart disease and poor prognosis in the elderly.American journal of translational research · 2023Article
- Increased levels of oral Streptococcus-derived D-alanine in patients with chronic kidney disease and diabetes mellitus.Scientific reports · 2022Article
- Periodontal Disease in Obese Patients; Interleukin-6 and C-Reactive Protein Study: A Systematic Review.Dentistry journal · 2022Review
- Periodontitis and Subsequent Risk of Cataract: Results From Real-World Practice.Frontiers in medicine · 2022Article
- Oral Hygiene Practices and Awareness of Pregnant Women about the Effects of Periodontal Disease on Pregnancy Outcomes.International journal of dentistry · 2022Article
- Plasmid encoding microRNA-200c ameliorates periodontitis and systemic inflammation in obese mice.Molecular therapy. Nucleic acids · 2021Article
- Predictive Value of Homeostasis Model Assessment of Insulin Resistance, Visceral Fat Index, and Prepregnancy Body Mass Index in Gestational Metabolic Syndrome.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- A Population-Based Study on the Association between Periodontal Disease and Major Lifestyle-Related Comorbidities in South Korea: An Elderly Cohort Study from 2002-2015.Medicina (Kaunas, Lithuania) · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The metabolic syndrome (MetS) (also known as insulin resistance syndrome, syndrome X) is a cluster of factors associated with increased risk of developing coronary heart disease or type 2 diabetes mellitus. Several studies in the past have reviewed an association between MetS and periodontitis. Periodontal disease is considered an infectious and chronic inflammatory disease, and it has been considered to be a potential risk in cardiovascular and respiratory diseases and diabetes, and has implications in adverse pregnancy outcomes, osteoporosis, and so on. These systemic disorders have been documented as capable of affecting the periodontium or treatment of periodontal disease. Oral inflammatory lesions have different basic mechanisms concerning the possible association with systemic diseases. They concern local spread, metastatic spread, or immunologic cross-reactivity. In many studies, sometimes contrasting, periodontal pathogens have been evaluated in atheromatous plaques isolated from patients with chronic periodontitis. Oral inflammatory lesions have been shown unequivocally to contribute to elevated systemic inflammatory responses. In some studies, intensive periodontal therapy showed a significant reduction in c-reactive protein levels, interleukin-6, and low-density lipoprotein cholesterol after 2 months. The aim of this article is to reflect the association between MetS and periodontitis and to suggest an understanding to promote interprofessional practice; with proper oral care and plaque control, we can reduce the severity of MetS.
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