Evidence map›Paper›PMID 31803626›Full record

ArticleFrontiers in oncology2019

Radiation-Induced Changes in Tumor Vessels and Microenvironment Contribute to Therapeutic Resistance in Glioblastoma.

Yun-Soo Seo, In Ok Ko, Hyejin Park, Ye Ji Jeong, Ji-Ae Park, Kwang Seok Kim, Myung-Jin Park, Hae-June Lee

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 47 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yun-Soo SeoDivision of Radiation Biomedical Research, Korea Institute of Radiological & Medical Sciences, Naju, South Korea.
In Ok KoDivision of Applied RI, Korea Institute of Radiological & Medical Science, Seoul, South Korea.
Hyejin ParkDivision of Radiation Biomedical Research, Korea Institute of Radiological & Medical Sciences, Naju, South Korea.
Ye Ji JeongDivision of Radiation Biomedical Research, Korea Institute of Radiological & Medical Sciences, Naju, South Korea.
Ji-Ae ParkDivision of Applied RI, Korea Institute of Radiological & Medical Science, Seoul, South Korea.
Kwang Seok KimDivision of Radiation Biomedical Research, Korea Institute of Radiological & Medical Sciences, Naju, South Korea.
Myung-Jin ParkDivision of Radiation Biomedical Research, Korea Institute of Radiological & Medical Sciences, Naju, South Korea.
Hae-June LeeDivision of Radiation Biomedical Research, Korea Institute of Radiological & Medical Sciences, Naju, South Korea.
Korea Institute of Radiological and Medical Sciences · KRKorea Institute of Oriental Medicine · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioblastoma (GBM) is a largely fatal and highly angiogenic malignancy with a median patient survival of just over 1 year with radiotherapy (RT). The effects of RT on GBM remain unclear, although increasing evidence suggests that RT-induced alterations in the brain microenvironment affect the recurrence and aggressiveness of GBM. Glioma stem cells (GSCs) in GBM are resistant to conventional therapies, including RT. This study aimed to investigate the effect of radiation on tumor growth and the GSC microenvironment in a mouse model of glioma. To evaluate the growth-inhibitory effects of ionizing radiation on GSCs, tumor volume was measured via anatomical magnetic resonance imaging (MRI) after the intracranial injection of 1 × 10

Indexed as

glioblastomaglioma stem cellradiotherapytumor microenvironmenttumor vessel

Identifiers

PMID31803626
PMCPMC6873882
OpenAlexW2987783843

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.