Evidence map›Paper›PMID 31803580›Full record

ArticlePublic health action2019

Targeted active screening for tuberculosis in Zimbabwe: are field digital chest X-ray ratings reliable?

C Timire, C Sandy, M Ngwenya, N Woznitza, A M V Kumar, K C Takarinda, T Sengai, A D Harries

Open access · diamondAbstract read
In one paragraph

Article in Public health action, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. TB prevalence in Zimbabwe: a national cross-sectional survey, 2014.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 4 countries.

C TimireMinistry of Health and Child Care, National AIDS & TB Programme, Harare, Zimbabwe.
C SandyMinistry of Health and Child Care, National AIDS & TB Programme, Harare, Zimbabwe.
M NgwenyaWorld Health Organization, Harare Country Office, Zimbabwe.
N WoznitzaHomerton University Hospital & Canterbury Christ Church University, London, UK.
A M V KumarThe Union, Paris, France.
K C TakarindaMinistry of Health and Child Care, National AIDS & TB Programme, Harare, Zimbabwe.
T SengaiFamily AIDS Caring Trust (FACT), Mutare, Zimbabwe.
A D HarriesThe Union, Paris, France.
International Union Against Tuberculosis and Lung Disease · FRCanterbury Christ Church University · GBFamily Aids Caring Trust · ZWLondon School of Hygiene & Tropical Medicine · GBMinistry of Health and Child Welfare · ZWWorld Health Organization - Zimbabwe · ZW

Funding

Training for Research Excellence and MeNtorship in Tuberculosis (TRENT)D43TW009539 · FIC · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI METCALFE, JOHN ZAPATA · 2013 to 2022
$2.9M
FIC NIH HHS D43 TW009539World Health Organization 001
6 · The paper itself

Abstract

settingFifteen purposively selected districts in Zimbabwe in which targeted active screening for tuberculosis (Tas4TB) was conducted among TB high-risk groups (HRGs). There were 230 patients started on TB treatment on the basis of chest X-ray (CXR) results without corresponding bacteriological confirmation.

objectivesTo determine 1) the percentage of agreements in digital CXR ratings by medical officers against final ratings by radiologist(s), 2) inter-rater agreement in CXR ratings between medical officers and radiologists, and 3) number (and proportion) of patients belonging to HRGs who were over-treated during Tas4TB.

designThis was a cross-sectional study using programme data.

resultsA total of 168 patients had their CXRs rated by two independent radiologists. Discordances among the radiologists were resolved by a third index radiologist, who provided the final rating. κ scores were 0.01 (field ratings vs. Radiologist A); 0.02 (field ratings vs. Radiologist B); 0.74 (Radiologists A vs. B). The percentage agreement for field and final radiologist rating was 70% (95%CI 64-78). Around 29% (95%CI 23-36) of the patients were potentially over-treated during Tas4TB.

conclusionOver a quarter of patients with presumptive TB are potentially over-treated during Tas4TB. Over-treatment is highest among those with previous contact with TB patients. Trainings of radiographers and medical officers may improve CXR ratings.

Indexed as

CXRdiagnostic accuracyhigh-risk groupinter-observer variabilitySORT-IT

Identifiers

PMID31803580
PMCPMC6827497
OpenAlexW2984206959

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.