Evidence map›Paper›PMID 31803464›Full record

ReviewTherapeutic advances in endocrinology and metabolism2019

Reduced physical activity in young and older adults: metabolic and musculoskeletal implications.

Kelly A Bowden Davies, Samuel Pickles, Victoria S Sprung, Graham J Kemp, Uazman Alam, Daniel R Moore, Abd A Tahrani, Daniel J Cuthbertson

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Therapeutic advances in endocrinology and metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 131 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
131citing papers in PubMed, 9 pooled it
17.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

131 citing papers in PubMed, 9 syntheses or guidelines pooled it, 263 citations in OpenAlex.

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71 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Kelly A Bowden DaviesSchool of Biomedical, Nutritional and Sport Sciences, Faculty of Medical Sciences, Newcastle University, Catherine Cookson Building M1.038, Newcastle upon Tyne, NE2 4HH, UK.ORCID https://orcid.org/0000-0002-9448-0732
Samuel PicklesInstitute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.
Victoria S SprungResearch Institute for Sport and Exercise Science, Liverpool John Moores University, Liverpool, UK.
Graham J KempInstitute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.
Uazman AlamInstitute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.
Daniel R MooreFaculty of Kinesiology and Physical Education, University of Toronto, Toronto, ON, Canada.
Abd A TahraniInstitute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Daniel J CuthbertsonInstitute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.
University of Liverpool · GBUniversity Hospitals Birmingham NHS Foundation Trust · GBUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough the health benefits of regular physical activity and exercise are well established and have been incorporated into national public health recommendations, there is a relative lack of understanding pertaining to the harmful effects of

resultsStep-reduction studies have largely focused on musculoskeletal and metabolic health parameters, providing relevant disease models for metabolic syndrome, type 2 diabetes (T2D), nonalcoholic fatty liver disease (NAFLD), sarcopenia and osteopenia/osteoporosis. In untrained individuals, even a short-term reduction in physical activity has a significant impact on skeletal muscle protein and carbohydrate metabolism, causing anabolic resistance and peripheral insulin resistance, respectively. From a metabolic perspective, short-term inactivity-induced peripheral insulin resistance in skeletal muscle and adipose tissue, with consequent liver triglyceride accumulation, leads to hepatic insulin resistance and a characteristic dyslipidaemia. Concomitantly, various inactivity-related factors contribute to a decline in

conclusionsPhysical inactivity maybe particularly deleterious in certain patient populations, such as those at high risk of T2D or in the elderly, considering concomitant sarcopenia or osteoporosis. The effects of short-term physical inactivity (with step reduction) are reversible on resumption of habitual physical activity in younger people, but less so in older adults. Nutritional interventions and resistance training offer potential strategies to prevent these deleterious metabolic and musculoskeletal effects. IMPACT: Individuals at high risk of/with cardiometabolic disease and older adults may be more prone to these acute periods of inactivity due to acute illness or hospitalization. Understanding the risks is paramount to implementing countermeasures.

Indexed as

anabolic resistancebody compositioninsulin resistanceliver fatphysical inactivityskeletal muscle

Identifiers

PMID31803464
PMCPMC6878603
OpenAlexW2989749654

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.