Evidence map›Paper›PMID 31803441›Full record

ArticleChemical science2019

Canonical DNA minor groove insertion of bisbenzamidine-Ru(ii) complexes with chiral selectivity.

Mateo I Sánchez, Gustavo Rama, Renata Calo-Lapido, Kübra Ucar, Per Lincoln, Miguel Vázquez López, Manuel Melle-Franco, José L Mascareñas, M Eugenio Vázquez

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Mateo I SánchezCentro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS) , Departamento de Química Orgánica , Universidade de Santiago de Compostela , 15782 Santiago de Compostela , Spain . Email: eugenio.vazquez@usc.es.ORCID 0000-0003-1359-6969
Gustavo RamaCentro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS) , Departamento de Química Inorgánica , Universidade de Santiago de Compostela , 15782 Santiago de Compostela , Spain.ORCID 0000-0003-1689-7775
Renata Calo-LapidoCentro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS) , Departamento de Química Orgánica , Universidade de Santiago de Compostela , 15782 Santiago de Compostela , Spain . Email: eugenio.vazquez@usc.es.
Kübra UcarDepartment of Chemistry and Chemical Engineering , Chalmers University of Technology , SE 412 96 Gothenburg , Sweden.
Per LincolnDepartment of Chemistry and Chemical Engineering , Chalmers University of Technology , SE 412 96 Gothenburg , Sweden.
Miguel Vázquez LópezCentro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS) , Departamento de Química Inorgánica , Universidade de Santiago de Compostela , 15782 Santiago de Compostela , Spain.ORCID 0000-0003-3376-3461
Manuel Melle-FrancoCiceco - Aveiro Institute of Materials , University of Aveiro Campus Universitario de Santiago , Aveiro , 3810-193 , Portugal.
José L MascareñasCentro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS) , Departamento de Química Orgánica , Universidade de Santiago de Compostela , 15782 Santiago de Compostela , Spain . Email: eugenio.vazquez@usc.es.ORCID 0000-0002-7789-700X
M Eugenio VázquezCentro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS) , Departamento de Química Orgánica , Universidade de Santiago de Compostela , 15782 Santiago de Compostela , Spain . Email: eugenio.vazquez@usc.es.ORCID 0000-0001-7500-985X
Universidade de Santiago de Compostela · ESChalmers University of Technology · SEUniversity of Aveiro · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report the first Ru(ii) coordination compounds that interact with DNA through a canonical minor groove insertion mode and with selectivity for A/T rich sites. This was made possible by integrating a bis-benzamidine minor groove DNA-binding agent with a ruthenium(ii) complex. Importantly, one of the enantiomers (Δ-[Ru(bpy)

Identifiers

PMID31803441
PMCPMC6849638
OpenAlexW2966289003

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.