Evidence map›Paper›PMID 31803286›Full record

ArticleJournal of medicine and life

Prognosis Factors in Chronic Lymphocytic Leukemia.

A M Ivanescu, M Oprea, R Momanu, E Coles, A Colita, A R Lupu

Open access · greenAbstract read
In one paragraph

Article in Journal of medicine and life. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 63% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

A M IvanescuHematology Department, Coltea Clinical Hospital, Bucharest.
M OpreaHematology Department, Coltea Clinical Hospital, Bucharest.
R MomanuRoche Romania, Bucharest.
E Coles"Carol Davila" University of Medicine and Pharmacy, Bucharest.
A ColitaHematology Department, Coltea Clinical Hospital, Bucharest.
A R LupuHematology Department, Coltea Clinical Hospital, Bucharest.
Carol Davila University of Medicine and Pharmacy · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic lymphocytic leukemia is still one of the most common hematologic malignancies. Finding a curative solution is the objective of numerous followed cases and clinical trials. Diagnosis is based on the interlocking of classic elements and newly identified prognostic factors but time to first treatment is still an open issue. CD38, ZAP 70, IgHV gene mutational status and cytogenetic changes are proven negatively influence the evolution of chronic lymphocytic leukemia. Whether through aggressive rapid evolution or by the difficulty of obtaining a complete remission or risk of early relapse, CLL is still important. Adapted to these prognostic factors, combined therapeutic regimens have proved to be effective in achieving a durable complete remission, new agents, with encouraging partial results, being studied. Requiring initial screening, for comparative purposes, a current and growing importance has minimal residual disease; its absence at the end of treatment represents a strong positive prognostic factor.

Indexed as

CD38CD38 - cluster of differentiation 38Chronic lymphocytic leukemiaCLL - Chronic lymphocytic leukemiaIgHVIGHV - immunoglobulin heavy chain variable region genesLDT - lymphocyte doubling timeNK - natural killer cellsprognosis factorsZAP70ZAP-70 the protein associated to zeta chain with the molecular weight of 70Kda

Identifiers

PMID31803286
PMCPMC6880207
OpenAlexW3025816291

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.