ArticleFrontiers in immunology2019
Caspase-11 Mediates Neutrophil Chemotaxis and Extracellular Trap Formation During Acute Gouty Arthritis Through Alteration of Cofilin Phosphorylation.
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In one paragraph
Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 2 pooled it
3.1field-weighted citation impact, top 7% of its field
What it found
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Who cites it
50 citing papers in PubMed, 2 syntheses or guidelines pooled it, 76 citations in OpenAlex.
- Effect of nanoparticles on gouty arthritis: a systematic review and meta-analysis.BMC musculoskeletal disorders · 2023Pooled it
- Efficacy and safety of Danggui Niantong Decoction in patients with gout: a systematic review and meta-analysis.Frontiers in pharmacology · 2023Pooled it
- Neutrophil Fate and Function in Gout: From Sterile Inflammation to Resolution.International journal of molecular sciences · 2026Review
- Non-pyroptotic caspase-11 activity regulates osteoclastogenesis and pathological bone loss.Cell death and differentiation · 2026Article
- Neutrophil extracellular traps in gout: from immune defense to pathological dynamic equilibrium.Frontiers in immunology · 2026Review
- From soluble uric acid to sodium urate crystal: immune metabolic inflammation driven by uric acid morphological transformation and mechanism-oriented therapy.Frontiers in immunology · 2026Review
- Spatiotemporal immune gradients in gout: immune response-driven activation of the NLRP3-IL-1β axis and its transition to trained immunity.Frontiers in immunology · 2026Review
- NETosis-specific cell death: a novel mechanism in the pathogenesis of gouty arthritis.European journal of medical research · 2025Review
- Regulatory Roles of Noncanonical Inflammasomes in Diabetes Mellitus and Diabetes-Associated Complications.International journal of molecular sciences · 2025Review
- Association between neutrophil-to-HDL cholesterol ratio and the risk of gout or hyperuricemia: evidence from NHANES 2007-2018.European journal of medical research · 2025Article
- The therapeutic mechanisms of quercetin on inflammatory diseases: an update.Inflammopharmacology · 2025Review
- Neutrophils: a new target for postoperative cognitive dysfunction.Apoptosis : an international journal on programmed cell death · 2025Review
- Integrating natural products with modern medicine in the treatment of gouty arthritis: a review.Inflammopharmacology · 2025Review
- The emerging role of neutrophil extracellular traps in autoimmune and autoinflammatory diseases.MedComm · 2025Review
- The Progress of Immune Cells-induced Inflammatory Response in Gout.Current pharmaceutical design · 2025Review
- The concealed side of caspases: beyond a killer of cells.Cellular and molecular life sciences : CMLS · 2024Review
- Kaempferol attenuates hyperuricemia combined with gouty arthritis via urate transporters and NLRP3/NF-κB pathway modulation.iScience · 2024Article
- DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates inflammation and amyloid-β deposition in Alzheimer's disease.Alzheimer's research & therapy · 2024Article
- Roles of the Caspase-11 Non-Canonical Inflammasome in Rheumatic Diseases.International journal of molecular sciences · 2024Review
- Dying to Defend: Neutrophil Death Pathways and their Implications in Immunity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
Corrections and comments
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Authors and funding
20 authors at 4 institutions in 2 countries.
Kyle CautionDepartment of Microbial Infection and Immunity, The Ohio State University Medical Center, Columbus, OH, United States.
Nicholas YoungDepartment of Rheumatology and Immunology, The Ohio State University Medical Center, Columbus, OH, United States.
Frank Robledo-AvilaCenter for Microbial Pathogenesis, Nationwide Children's Hospital, Columbus, OH, United States.
Kathrin KrauseDepartment of Microbial Infection and Immunity, The Ohio State University Medical Center, Columbus, OH, United States.
Arwa Abu KhweekDepartment of Microbial Infection and Immunity, The Ohio State University Medical Center, Columbus, OH, United States.
Kaitlin HamiltonDepartment of Microbial Infection and Immunity, The Ohio State University Medical Center, Columbus, OH, United States.
Asmaa BadrDepartment of Microbial Infection and Immunity, The Ohio State University Medical Center, Columbus, OH, United States.
Anup VaidyaDepartment of Microbial Infection and Immunity, The Ohio State University Medical Center, Columbus, OH, United States.
Kylene DailyDepartment of Microbial Infection and Immunity, The Ohio State University Medical Center, Columbus, OH, United States.
Hawin GosuDepartment of Microbial Infection and Immunity, The Ohio State University Medical Center, Columbus, OH, United States.
Midhun N K AnneDepartment of Microbial Infection and Immunity, The Ohio State University Medical Center, Columbus, OH, United States.
Mostafa EltobgyDepartment of Microbial Infection and Immunity, The Ohio State University Medical Center, Columbus, OH, United States.
Duaa DakhlallahDepartment of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV, United States.
Sudha ArgwalDepartment of Rheumatology and Immunology, The Ohio State University Medical Center, Columbus, OH, United States.
Shady EstfanousDepartment of Microbial Infection and Immunity, The Ohio State University Medical Center, Columbus, OH, United States.
Xiaoli ZhangCenter for Biostatistics, The Ohio State University Medical Center, Columbus, OH, United States.
Santiago Partida-SanchezCenter for Microbial Pathogenesis, Nationwide Children's Hospital, Columbus, OH, United States.
Mikhail A GavrilinDepartment of Internal Medicine, The Ohio State University Medical Center, Columbus, OH, United States.
Wael N JarjourDepartment of Rheumatology and Immunology, The Ohio State University Medical Center, Columbus, OH, United States.
Amal O AmerDepartment of Microbial Infection and Immunity, The Ohio State University Medical Center, Columbus, OH, United States.
The Ohio State University Wexner Medical Center · USThe Ohio State University · USNationwide Children's Hospital · USWest Virginia University · US
Funding
West Virginia IDEA-CTRU54GM104942 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Sally Lynn Hodder · 2012 to 2026
$81.0MThe Ohio State University Center for clinical and Translational ScienceUL1TR001070 · NCATS · OHIO STATE UNIVERSITY · PI JACKSON, REBECCA D · 2013 to 2017
$22.6MMacrophage Inflammasome RegulationR01HL076278 · NHLBI · OHIO STATE UNIVERSITY · PI WEWERS, MARK DAMIAN · 2005 to 2019
$4.5MUnraveling the role of the CFTR ion channel in susceptibility to SARS-CoV-2 infection and inflammationR01AI124121 · NIAID · OHIO STATE UNIVERSITY · PI AMER, AMAL O, CORMET-BOYAKA, ESTELLE A · 2016 to 2020
$3.7MRole of caspases in Legionella pneumophila pulmonary infectionR01HL094586 · NHLBI · OHIO STATE UNIVERSITY · PI AMER, AMAL O · 2009 to 2013
$1.9MThe role of microRNA-calibrated autophagy in innate immunity and inflammationR01HL127651 · NHLBI · OHIO STATE UNIVERSITY · PI AMER, AMAL O, CORMET-BOYAKA, ESTELLE A · 2015 to 2018
$1.5MHuman susceptibility to Legionella infectionR21AI113477 · NIAID · OHIO STATE UNIVERSITY · PI AMER, AMAL O · 2015 to 2016
$434kNCATS NIH HHS UL1 TR001070NHLBI NIH HHS R01 HL076278NHLBI NIH HHS R01 HL094586NHLBI NIH HHS R01 HL127651NIAID NIH HHS R01 AI124121NIAID NIH HHS R21 AI113477NIGMS NIH HHS U54 GM104942
Abstract
Gout is characterized by attacks of arthritis with hyperuricemia and monosodium urate (MSU) crystal-induced inflammation within joints. Innate immune responses are the primary drivers for tissue destruction and inflammation in gout. MSU crystals engage the Nlrp3 inflammasome, leading to the activation of caspase-1 and production of IL-1β and IL-18 within gout-affected joints, promoting the influx of neutrophils and monocytes. Here, we show that
Indexed as
Actin Depolymerizing FactorsAcute DiseaseAnimalsArthritis, GoutyBiomarkersCaspases, InitiatorChemotaxisCytokinesDisease Models, AnimalDisease SusceptibilityExtracellular TrapsGene ExpressionImmunohistochemistryImmunophenotypingInflammasomesInflammation MediatorsActin Depolymerizing FactorsBiomarkersCaspases, InitiatorCytokinesInflammasomesInflammation MediatorsMLKL protein, mouseProtein KinasesReceptor-Interacting Protein Serine-Threonine KinasesRipk3 protein, mousecaspase-11cell migrationgoutIL-1βinflammasomemacrophagesNETosisneutrophils
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.