Evidence map›Paper›PMID 31803157›Full record

ArticleFrontiers in microbiology2019

Profiling of Protein Degraders in Cultures of Human Gut Microbiota.

Alberto Amaretti, Caterina Gozzoli, Marta Simone, Stefano Raimondi, Lucia Righini, Vicente Pérez-Brocal, Rodrigo García-López, Andrés Moya, Maddalena Rossi

Abstract read
In one paragraph

Article in Frontiers in microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Review
  5. Microbiota-derived indole limitsScience advances · 2026
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  7. Article
  8. Review
  9. Review
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  13. Bacterial iron acquisition byProceedings of the National Academy of Sciences of the United States of America · 2026
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  15. Article
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  19. Review
  20. Article

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alberto AmarettiDepartment of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Caterina GozzoliDepartment of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Marta SimoneDepartment of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Stefano RaimondiDepartment of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Lucia RighiniDepartment of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Vicente Pérez-BrocalArea of Genomics and Health, Foundation for the Promotion of Sanitary and Biomedical Research of Valencian Community (FISABIO-Public Health), Valencia, Spain.
Rodrigo García-LópezArea of Genomics and Health, Foundation for the Promotion of Sanitary and Biomedical Research of Valencian Community (FISABIO-Public Health), Valencia, Spain.
Andrés MoyaArea of Genomics and Health, Foundation for the Promotion of Sanitary and Biomedical Research of Valencian Community (FISABIO-Public Health), Valencia, Spain.
Maddalena RossiDepartment of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Unabsorbed proteins reach the colon and are fermented by the microbiota, yielding a variety of harmful metabolites. In the present study, a 16S rRNA gene survey identified the bacterial taxa flourishing in 11 batch fermentations with proteins and peptones as the sole fermentable substrates, inoculated with the feces of six healthy adults. Organic acids, ammonia, and indole resulting from protein breakdown and fermentation accumulated in all of the cultures. Analysis of differential abundances among time-points identified Enterobacteriaceae, Burkholderiaceae, and Desulfovibrionaceae (including

Indexed as

enrichment cultureEnterobacteriaceaegut microbiotametagenomicsproteolysis

Identifiers

PMID31803157
PMCPMC6874058

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.