ReviewFrontiers in neuroscience2019
Successes and Hurdles in Stem Cells Application and Production for Brain Transplantation.
Review in Frontiers in neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Understanding the cellular dynamics, engineering perspectives and translation prospects in bioprinting epithelial tissues.Bioactive materials · 2025Review
- Classes of Stem Cells: From Biology to Engineering.Regenerative engineering and translational medicine · 2024Article
- Graft-derived neurons and bystander effects are maintained for six months after human iPSC-derived NESC transplantation in mice's cerebella.Scientific reports · 2024Article
- Alzheimer's Disease Treatment: The Search for a Breakthrough.Medicina (Kaunas, Lithuania) · 2023Review
- An In Vivo Platform for Rebuilding Functional Neocortical Tissue.Bioengineering (Basel, Switzerland) · 2023Article
- The Wisdom in Teeth: Neuronal Differentiation of Dental Pulp Cells.Cellular reprogramming · 2023Review
- Circuit formation in the adult brain.The European journal of neuroscience · 2022Review
- Establishment and characterization of human pluripotent stem cells-derived brain organoids to model cerebellar diseases.Scientific reports · 2022Article
- Stem Cell Therapy for Neuroprotection in the Growth-Restricted Newborn.Stem cells translational medicine · 2022Review
- Biomaterials enhancing performance of cell and nucleic-acid therapies: An opportunity in the brain.Biomaterials and biosystems · 2022Article
- Derivation of Multipotent Neural Progenitors from Human Embryonic Stem Cells for Cell Therapy and Biomedical Applications.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Stem Cell Therapy for Modulating Neuroinflammation in Neuropathic Pain.International journal of molecular sciences · 2021Review
- Advances and Perspectives in Dental Pulp Stem Cell Based Neuroregeneration Therapies.International journal of molecular sciences · 2021Review
- Neural Differentiation of Mouse Embryonic Stem Cells-AnFrontiers in genetics · 2021Article
- A Century of Brain Regeneration Phenomena and Neuromorphological Research Advances, 1890s-1990s-Examining the Practical Implications of Theory Dynamics in Modern Biomedicine.Frontiers in cell and developmental biology · 2021Review
- Biomaterials for Neurotherapeutics: From Lab Discovery to Clinical Application.Current neuropharmacology · 2021Article
- Oligodendrocyte Development and Implication in Perinatal White Matter Injury.Frontiers in cellular neuroscience · 2021Review
- Cell-Based Delivery Approaches for DNA-Binding Domains to the Central Nervous System.Current neuropharmacology · 2021Review
- Therapeutic Targeting Strategies for Early- to Late-Staged Alzheimer's Disease.International journal of molecular sciences · 2020Review
- Diminished expression of major histocompatibility complex facilitates the use of human induced pluripotent stem cells in monkey.Stem cell research & therapy · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brain regenerative strategies through the transplantation of stem cells hold the potential to promote functional rescue of brain lesions caused either by trauma or neurodegenerative diseases. Most of the positive modulations fostered by stem cells are fueled by bystander effects, namely increase of neurotrophic factors levels and reduction of neuroinflammation. Nevertheless, the ultimate goal of cell therapies is to promote cell replacement. Therefore, the ability of stem cells to migrate and differentiate into neurons that later become integrated into the host neuronal network replacing the lost neurons has also been largely explored. However, as most of the preclinical studies demonstrate, there is a small functional integration of graft-derived neurons into host neuronal circuits. Thus, it is mandatory to better study the whole brain cell therapy approach in order to understand what should be better comprehended concerning graft-derived neuronal and glial cells migration and integration before we can expect these therapies to be ready as a viable solution for brain disorder treatment. Therefore, this review discusses the positive mechanisms triggered by cell transplantation into the brain, the limitations of adult brain plasticity that might interfere with the neuroregeneration process, as well as some strategies tested to overcome some of these limitations. It also considers the efforts that have been made by the regulatory authorities to lead to better standardization of preclinical and clinical studies in this field in order to reduce the heterogeneity of the obtained results.
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