ArticleOncoTargets and therapy2019
Circular RNA
Article in OncoTargets and therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 49 citations in OpenAlex.
- CircRNAs in colorectal cancer: potential roles, clinical applications, and natural product-based regulation.Frontiers in oncology · 2025Review
- miRNA-214-3p stimulates carcinogen-induced mammary epithelial cell apoptosis in mammary cancer-resistant species.Communications biology · 2023Article
- Role of circ-FOXO3 and miR-23a in radiosensitivity of breast cancer.Breast cancer (Tokyo, Japan) · 2023Article
- Modulating epigenetic modifications for cancer therapy (Review).Oncology reports · 2023Review
- CircRNA has_circ_0017109 promotes lung tumor progression via activation of Wnt/β-catenin signaling due to modulating miR-671-5p/FZD4 axis.BMC pulmonary medicine · 2022Article
- Effect of circRNA_FOXO3 rs12196996 polymorphism and FOXO3 rs2232365 polymorphism on survival rate and severity of intensive care unit-acquired sepsis.Bioengineered · 2022Article
- Circular RNA in cancer development and immune regulation.Journal of cellular and molecular medicine · 2022Review
- Review
- The regulatory roles of circular RNAsFrontiers in neurology · 2022Review
- Novel Pyroptosis-Related Gene Signatures Identified as the Prognostic Biomarkers for Bladder Carcinoma.Frontiers in oncology · 2022Article
- Circular RNA FOXO3 regulates endometrial carcinoma progression through the microRNA-29a-3p/HDAC4 axis.American journal of translational research · 2022Article
- The Circular RNA CircCOL1A1 Functions as a miR-149-5p Sponge to Regulate the Formation of Superior-Quality Brush HairFrontiers in cell and developmental biology · 2022Article
- The Role of Circular RNAs in the Carcinogenesis of Bladder Cancer.Frontiers in oncology · 2022Review
- Circular RNAs in prostate cancer: Biogenesis,biological functions, and clinical significance.Molecular therapy. Nucleic acids · 2021Review
- From circRNAs to fusion circRNAs in hematological malignancies.JCI insight · 2021Review
- Article
- Review
- Functions of circular RNAs in bladder, prostate and renal cell cancer (Review).Molecular medicine reports · 2021Review
- Circular RNA hsa_circ_0001666 sponges miR‑330‑5p, miR‑193a‑5p and miR‑326, and promotes papillary thyroid carcinoma progression via upregulation of ETV4.Oncology reports · 2021Article
- Pathogenic mechanisms and the potential clinical value of circFoxo3 in cancers.Molecular therapy. Nucleic acids · 2021Review
Corrections and comments
- Retraction · 2023-08-11Concerns/Issues about Data · Duplication of/in Image · Original Data and/or Images not Provided and/or not Available · Unreliable Results and/or Conclusions ·
- RetractedCircular RNA2023
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCircular RNAs (circRNAs) play a critical role in cancer. Emerging evidence has shown circ-Foxo3, a circRNA, was dysregulated in a variety of tumor types. However, the exact role of
methodsWe measured the expression level of circ-Foxo3 in human and murine bladder cancer tissues and in various human bladder cancer cell lines. We induced bladder cancer in mice by a carcinogen N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN). circ-Foxo3 was overexpressed in mice by lentiviral gene transfer and in cultured cells via overexpression plasmid. The effect of circ-Foxo3 on apoptosis was examined via apoptotic marker staining, Western blot, and flow cytometry. We further characterized the interaction between circ-Foxo3 and miR-191 and its functional impact on bladder cancer cells.
resultscirc-Foxo3 was downregulated in bladder cancer in vivo and in vitro, and was upregulated in response to apoptotic stress. Overexpression of circ-Foxo3 promoted bladder cancer cell apoptosis in BBN mice and in human bladder cancer cell lines. miR-191-5p suppressed circ-Foxo3 expression and the pro-apoptotic effect of
conclusioncirc-Foxo3 was downregulated in bladder cancer in vivo and in vitro, and promoted bladder cancer apoptosis via direct interaction with miR-191. circ-Foxo3 could be a potential therapeutic target for bladder cancer.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.