ArticleInternational journal of nanomedicine2019
CTGF Loaded Electrospun Dual Porous Core-Shell Membrane For Diabetic Wound Healing.
Article in International journal of nanomedicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- Electrospun Membranes for Diabetic Wound Healing: Advances, Challenges, and Future Directions.Advanced healthcare materials · 2026Review
- Electrospun PLA/PVP K90 Biphasic-Release Sublingual Film for Motion Sickness Treatment.Biomolecules · 2026Article
- Poly (d, l-lactide)/polyvinyl alcohol-based injectable microspheres with inflammation alleviation and cartilage regeneration enhancement for treatment of temporomandibular joints osteoarthritis.Regenerative biomaterials · 2026Article
- Mechanisms and Interventions of Diabetic Wound Healing.Current diabetes reviews · 2026Review
- Triaxial Electrospun Nanofiber Membranes for Prolonged Curcumin Release in Dental Applications: Drug Release and Biological Properties.Molecules (Basel, Switzerland) · 2025Article
- Electrospinning strategies targeting fibroblast for wound healing of diabetic foot ulcers.APL bioengineering · 2025Review
- Beyond the shell: exploring polymer-lipid interfaces in core-shell nanofibers to carry hyaluronic acid and β-caryophyllene.Beilstein journal of nanotechnology · 2025Article
- Article
- Mesenchymal stem cell therapy in diabetic foot ulcer: An updated comprehensive review.Health science reports · 2024Article
- An Insight into Biodegradable Polymers and their Biomedical Applications for Wound Healing.Current pharmaceutical design · 2024Review
- Enhancing diabetic wound healing: advances in electrospun scaffolds from pathogenesis to therapeutic applications.Frontiers in bioengineering and biotechnology · 2024Review
- State-of-the-Art Review of Advanced Electrospun Nanofiber Composites for Enhanced Wound Healing.AAPS PharmSciTech · 2023Review
- Inorganic/organic combination: Inorganic particles/polymer composites for tissue engineering applications.Bioactive materials · 2023Article
- Electrospinning Nanofibers as a Dressing to Treat Diabetic Wounds.Pharmaceutics · 2023Review
- Advances in Zebrafish for Diabetes Mellitus with Wound Model.Bioengineering (Basel, Switzerland) · 2023Review
- Therapeutic Efficacy of Polymeric Biomaterials in Treating Diabetic Wounds-An Upcoming Wound Healing Technology.Polymers · 2023Review
- Biodegradable Electrospun Scaffolds as an Emerging Tool for Skin Wound Regeneration: A Comprehensive Review.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Engineered biomimetic micro/nano-materials for tissue regeneration.Frontiers in bioengineering and biotechnology · 2023Review
- Release of ranibizumab using a porous poly(dimethylsiloxane) capsule suppressed laser-induced choroidal neovascularization via the transscleral route.Journal of materials science. Materials in medicine · 2022Article
- Advances in the Preparation of Nanofiber Dressings by Electrospinning for Promoting Diabetic Wound Healing.Biomolecules · 2022Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeImpairment of wound healing is a major issue in type-2 diabetes that often causes chronic infections, eventually leading to limb and/or organ amputation. Connective tissue growth factor (CTGF) is a signaling molecule with several roles in tissue repair and regeneration including promoting cell adhesion, cell migration, cell proliferation and angiogenesis. Incorporation of CTGF in a biodegradable core-shell fiber to facilitate its sustained release is a novel approach to promote angiogenesis, cell migration and facilitate wound healing. In this paper, we report the development of CTGF encapsulated electrospun dual porous PLA-PVA core-shell fiber based membranes for diabetic wound healing applications.
methodsThe membranes were fabricated by a core-shell electrospinning technique. CTGF was entrapped within the PVA core which was coated by a thin layer of PLA. The developed membranes were characterized by techniques such as Scanning Electron Microscopy (SEM), Fourier Transform Infrared Spectroscopy (FTIR) and X-Ray Diffraction (XRD) analysis. In vitro cell culture studies using fibroblasts, keratinocytes and endothelial cells were performed to understand the effect of CTGF loaded membranes on cell proliferation, cell viability and cell migration. A chicken chorioallantoic membrane (CAM) assay was performed to determine the angiogenic potential of the membranes.
resultsResults showed that the developed membranes were highly porous in morphology with secondary pore formation on the surface of individual fibers. In vitro cell culture studies demonstrated that CTGF loaded core-shell membranes improved cell viability, cell proliferation and cell migration. A sustained release of CTGF from the core-shell fibers was observed for an extended time period. Moreover, the CAM assay showed that core-shell membranes incorporated with CTGF can enhance angiogenesis.
conclusionOwing to the excellent cell proliferation, migration and angiogenic potential of CTGF loaded core-shell PLA-PVA fibrous membranes, they can be used as an excellent wound dressing membrane for treating diabetic wounds and other chronic ulcers.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.