Evidence map›Paper›PMID 31802783›Full record

ArticleTetrahedron letters2019

Microwave-assisted, rapid synthesis of 2-vinylquinolines and evaluation of their antimalarial activity.

Guang Huang, Claribel Murillo Solano, Yuxin Su, Nameer Ezzat, Shino Matsui, Liuyu Huang, Debopam Chakrabarti, Yu Yuan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tetrahedron letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Triflamides and Triflimides: Synthesis and Applications.Molecules (Basel, Switzerland) · 2022
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Guang HuangDepartment of Chemistry, University of Central Florida, Orlando, FL, USA.
Claribel Murillo SolanoDivision of Molecular Microbiology, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL, USA.
Yuxin SuAcademy of Military Medical Science, Beijing, China.
Nameer EzzatDepartment of Chemistry, University of Central Florida, Orlando, FL, USA.
Shino MatsuiDepartment of Chemistry, University of Central Florida, Orlando, FL, USA.
Liuyu HuangChinese PLA Center for Disease Control and Prevention, Beijing, China.
Debopam ChakrabartiDivision of Molecular Microbiology, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL, USA.
Yu YuanDepartment of Chemistry, University of Central Florida, Orlando, FL, USA.
University of Central Florida · USAcademy of Military Medical Sciences · CN

Funding

Discovery of Antimalarials with Novel Mechanism of ActionR01AI131398 · NIAID · UNIVERSITY OF CENTRAL FLORIDA · PI CHAKRABARTI, DEBOPAM · 2018 to 2022
$1.7M
Natural Product-Inspired Novel Synthetic Antiplasmodial ScaffoldsR03AI117298 · NIAID · UNIVERSITY OF CENTRAL FLORIDA · PI CHAKRABARTI, DEBOPAM · 2015 to 2016
$144k
NIAID NIH HHS R01 AI131398NIAID NIH HHS R03 AI117298
6 · The paper itself

Abstract

A rapid and efficient synthesis of 2-vinylquinolines via trifluoromethanesulfonamidemediated olefination of 2-methylquinoline and aldehyde under microwave irradiation is reported. Biological evaluation of these scaffolds demonstrates that 2-vinylquinolines

Indexed as

2-methylquinoline2-vinylquinolineantimalarialmicrowave-assisted synthesisolefination

Identifiers

PMID31802783
PMCPMC6892474
OpenAlexW2947455996

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.