Evidence map›Paper›PMID 31802699›Full record

ArticleTissue engineering. Part C, Methods2020

A Comparison of Sterilization Techniques for Production of Decellularized Intestine in Mice.

Carolyn Gosztyla, Mitchell R Ladd, Adam Werts, William Fulton, Blake Johnson, Chhinder Sodhi, David J Hackam

Open access · greenAbstract read
In one paragraph

Article in Tissue engineering. Part C, Methods, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

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  7. ECM roles and biomechanics in cardiac tissue decellularization.American journal of physiology. Heart and circulatory physiology · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Carolyn GosztylaDivision of Pediatric, Department of Surgery, Johns Hopkins University, Baltimore, Maryland.
Mitchell R LaddDivision of Pediatric, Department of Surgery, Johns Hopkins University, Baltimore, Maryland.
Adam WertsDepartment of Comparative Physiology, Johns Hopkins University, Baltimore, Maryland.
William FultonDivision of Pediatric, Department of Surgery, Johns Hopkins University, Baltimore, Maryland.
Blake JohnsonDivision of Pediatric, Department of Surgery, Johns Hopkins University, Baltimore, Maryland.
Chhinder SodhiDivision of Pediatric, Department of Surgery, Johns Hopkins University, Baltimore, Maryland.
David J HackamDivision of Pediatric, Department of Surgery, Johns Hopkins University, Baltimore, Maryland.
Johns Hopkins University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tissue-engineered small intestinal implants are being widely investigated as a potential treatment for children with short bowel syndrome, yet are currently limited by their growth potential and relatively low surface area. To address this gap in the field, several investigators have utilized whole organ decellularization of the small intestine as a platform for subsequent growth of intestinal tissue. However, such scaffold-cell constructs require sterilization as a prerequisite for implantation, and the effects of the different pathogen-clearance techniques used on the tissue architecture remains unknown. The effects of four different published protocols for pathogen clearance of decellularized intestine, namely 0.1% peracetic acid (PAA), 0.18% PAA +4.8% ethanol (EtOH), 0.08% PAA +1% hydrogen peroxide (H

Indexed as

AnimalsCell-Free SystemExtracellular MatrixIntestine, SmallMiceMice, Inbred C57BLRatsRats, Inbred LewSterilizationTissue EngineeringTissue Scaffoldsartificial intestinedecellularized intestineshort bowel syndrome

Identifiers

PMID31802699
PMCPMC7041403
OpenAlexW2992995811

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.