Evidence map›Paper›PMID 31802614›Full record

ArticleJournal of cellular and molecular medicine2020

Platelet sonicates activate hair follicle stem cells and mediate enhanced hair follicle regeneration.

Meishu Zhu, Deqiang Kong, Ruiyun Tian, Mengru Pang, Miaohua Mo, Yu Chen, Guang Yang, Hanghang Liu Cheng, Xiaoxuan Lei, Kunwu Fang and 2 more

Abstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Meishu ZhuThe Graduate School of Southern Medical University, Guangzhou, China.
Deqiang KongThe Shenzhen Key Laboratory of Health Sciences and Technology, Tsinghua Shenzhen International Graduate School, and Tsinghua-Berkeley Shenzhen Institute (TBSI), Tsinghua University, Shenzhen, China.ORCID 0000-0002-4897-7182
Ruiyun TianThe Shenzhen Key Laboratory of Health Sciences and Technology, Tsinghua Shenzhen International Graduate School, and Tsinghua-Berkeley Shenzhen Institute (TBSI), Tsinghua University, Shenzhen, China.
Mengru PangThe Graduate School of Southern Medical University, Guangzhou, China.
Miaohua MoThe Shenzhen Key Laboratory of Health Sciences and Technology, Tsinghua Shenzhen International Graduate School, and Tsinghua-Berkeley Shenzhen Institute (TBSI), Tsinghua University, Shenzhen, China.
Yu ChenThe Shenzhen Key Laboratory of Health Sciences and Technology, Tsinghua Shenzhen International Graduate School, and Tsinghua-Berkeley Shenzhen Institute (TBSI), Tsinghua University, Shenzhen, China.
Guang YangThe Shenzhen Key Laboratory of Health Sciences and Technology, Tsinghua Shenzhen International Graduate School, and Tsinghua-Berkeley Shenzhen Institute (TBSI), Tsinghua University, Shenzhen, China.
Hanghang Liu ChengKey Laboratory of Tissue Repair and Regeneration of PLA, and Beijing Key Research Laboratory of Skin Injury, Repair and Regeneration, The Fourth Medical Center of General Hospital of PLA, Beijing, China.
Xiaoxuan LeiDepartment of Burn & Plastic Surgery, the First Affiliated Hospital of Shenzhen University, Health Science Center, the Second People's Hospital of Shenzhen, Shenzhen, China.
Kunwu FangDepartment of Burn & Plastic Surgery, the First Affiliated Hospital of Shenzhen University, Health Science Center, the Second People's Hospital of Shenzhen, Shenzhen, China.
Biao ChengThe Graduate School of Southern Medical University, Guangzhou, China.
Yaojiong WuThe Shenzhen Key Laboratory of Health Sciences and Technology, Tsinghua Shenzhen International Graduate School, and Tsinghua-Berkeley Shenzhen Institute (TBSI), Tsinghua University, Shenzhen, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An increasing number of studies show that platelet-rich plasma (PRP) is effective for androgenic alopecia (AGA). However, the underlying cellular and molecular mechanisms along with its effect on hair follicle stem cells are poorly understood. In this study, we designed to induce platelets in PRP to release factors by calcium chloride (PC) or by sonication where platelet lysates (PS) or the supernatants of platelet lysate (PSS) were used to evaluate their effect on the hair follicle activation and regeneration. We found that PSS and PS exhibited a superior effect in activating telogen hair follicles than PC. In addition, PSS injection into the skin activated quiescent hair follicles and induced K15

Indexed as

SonicationAnimalsBlood PlateletsCell ProliferationCell SurvivalHaCaT CellsHair FollicleHumansIntercellular Signaling Peptides and ProteinsMaleMice, Inbred BALB CMice, Inbred C57BLPlatelet-Rich PlasmaRegenerationStem CellsIntercellular Signaling Peptides and Proteinsandrogenic alopeciahair follicle regenerationhair follicle stem cellsplatelet-rich plasmaplatelet sonicate

Identifiers

PMID31802614
PMCPMC6991668

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.