ReviewPrenatal diagnosis2020
The MRI spectrum of congenital cytomegalovirus infection.
Review in Prenatal diagnosis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed.
- Fetal Hepatosplenomegaly: Stepwise Diagnostic Framework, Diagnostic Approach to Fetal Hepatosplenomegaly.Journal of clinical medicine · 2026Review
- Article
- Prenatal ultrasound findings associated with intrauterine CMV infection: a multicenter retrospective analysis of clinical and sonographic features.BMC pregnancy and childbirth · 2026Observational
- Universal saliva PCR screening for congenital cytomegalovirus identifies asymptomatic infections with neuroimaging abnormalities in a prospective neonatal cohort.European journal of pediatrics · 2026Observational
- Optimization of fetal brain MRI at 0.55 T with slice-to-volume reconstruction.Magma (New York, N.Y.) · 2026Article
- Role of Ultrasound and Fetal MRI in the Prenatal Assessment of Congenital Cytomegalovirus Infection: A Systematic Review.Journal of clinical medicine · 2026Review
- Morphological patterns of fetal lateral ventricular border irregularities: descriptive study.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2026Article
- Impact of Maternal Valaciclovir Therapy on Early Neurodevelopment in Congenital CMV Infection: A Retrospective Pilot Study.Children (Basel, Switzerland) · 2026Article
- Review
- Paediatric cranial ultrasound: abnormalities of the brain in term neonates and young infants.Insights into imaging · 2025Article
- Brain Metabolite Differences in Fetuses With Cytomegalovirus Infection: A Magnetic Resonance Spectroscopy Study.Journal of magnetic resonance imaging : JMRI · 2025Article
- Diagnosis of Congenital Cytomegalovirus in a 14-Month-Old Patient Presenting with Sensorineural Hearing Loss: Storing Dry Blood Samples.Turkish archives of pediatrics · 2025Article
- Callosal Injuries in Cytomegalovirus Fetopathy: A Neurosonographic Study.Fetal diagnosis and therapy · 2025Article
- Article
- Evaluation of Congenital Cytomegalovirus Infection in Pregnant Women Admitted to a University Hospital in Istanbul.Viruses · 2024Article
- The Auditory Pathway in Congenitally Cytomegalovirus-Infected Human Fetuses.International journal of molecular sciences · 2024Article
- Infantile epileptic spasms syndrome in a child with lissencephaly associated withEpilepsy & behavior reports · 2024Article
- Magnetic resonance imaging of disorders with white matter changes in children and adolescents: a pictorial essay.Pediatric radiology · 2023Review
- Article
- Fetal MRI at 3 T: Principles to Optimize Success.Radiographics : a review publication of the Radiological Society of North America, Inc · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human cytomegalovirus (CMV) is an ubiquitous pathogen, with a high worldwide seroprevalence. When acquired in the prenatal period, congenital CMV (cCMV) is a major cause of neurodevelopmental sequelae and hearing loss. cCMV remains an underdiagnosed condition, with no systematic screening implemented in pregnancy or in the postnatal period. Therefore, imaging takes a prominent role in prenatal diagnosis of cCMV. With the prospect of new viable therapies, accurate and timely diagnosis becomes paramount, as well as identification of fetuses at risk for neurodevelopmental sequelae. Fetal magnetic resonance imaging (MRI) provides a complementary method to ultrasound (US) in fetal brain and body imaging. Anterior temporal lobe lesions are the most specific finding, and MRI is superior to US in their detection. Other findings such as ventriculomegaly, cortical malformations and calcifications, as well as hepatosplenomegaly, liver signal changes and abnormal effusions are unspecific. However, when seen in combination these should raise the suspicion of fetal infection, highlighting the need for a full fetal assessment. Still, some fetuses deemed normal on prenatal imaging are symptomatic at birth or develop delayed cCMV-associated symptoms, leaving room for improvement of diagnostic tools. Advanced MR sequences may help in this field and in determining prognosis, but further studies are needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.