Trial reportNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2020
Brain-Machine Interface Induced Morpho-Functional Remodeling of the Neural Motor System in Severe Chronic Stroke.
Trial report in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- The effect of brain-computer interface controlled functional electrical stimulation training on rehabilitation of upper limb after stroke: a systematic review and meta-analysis.Frontiers in human neuroscience · 2024Pooled it
- Hand-worn devices for assessment and rehabilitation of motor function and their potential use in BCI protocols: a review.Frontiers in human neuroscience · 2023Pooled it
- Brain-Computer Interfaces: The Dawn of a New Era in Disease Treatment.Exploration (Beijing, China) · 2026Review
- Advances in mechanisms of neuroplasticity induced by multimodal closed-loop brain-computer interfaces after stroke.Frontiers in human neuroscience · 2026Review
- Application of biomimetic approaches in the treatment of neurological disorders.Materials today. Bio · 2025Review
- Extension of voxel-based lesion mapping to multidimensional neurophysiological data.Scientific reports · 2025Article
- Uncovering attempted movements of the paralyzed upper limb after stroke through EEG and EMG.Journal of neuroengineering and rehabilitation · 2025Article
- Towards Predictive Communication: The Fusion of Large Language Models and Brain-Computer Interface.Sensors (Basel, Switzerland) · 2025Review
- The ReHand-BCI trial: a randomized controlled trial of a brain-computer interface for upper extremity stroke neurorehabilitation.Frontiers in neuroscience · 2025Article
- Functional MRI Assessment of Brain Activity Patterns Associated with Reading in Medulloblastoma Survivors.Brain sciences · 2024Article
- Self-Regulation of the Posterior-Frontal Brain Activity with Real-Time fMRI Neurofeedback to Influence Perceptual Discrimination.Brain sciences · 2024Article
- Research hotspots and trends of brain-computer interface technology in stroke: a bibliometric study and visualization analysis.Frontiers in neuroscience · 2023Article
- Challenges of neural interfaces for stroke motor rehabilitation.Frontiers in human neuroscience · 2023Article
- Optimization of Surface Electromyography-Based Neurofeedback Rehabilitation Intervention System.Journal of healthcare engineering · 2021Article
- An Inter- and Intra-Subject Transfer Calibration Scheme for Improving Feedback Performance of Sensorimotor Rhythm-Based BCI Rehabilitation.Frontiers in neuroscience · 2020Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brain-machine interfaces (BMI) permit bypass motor system disruption by coupling contingent neuroelectric signals related to motor activity with prosthetic devices that enhance afferent and proprioceptive feedback to the somatosensory cortex. In this study, we investigated neural plasticity in the motor network of severely impaired chronic stroke patients after an EEG-BMI-based treatment reinforcing sensorimotor contingency of ipsilesional motor commands. Our structural connectivity analysis revealed decreased fractional anisotropy in the splenium and body of the corpus callosum, and in the contralesional hemisphere in the posterior limb of the internal capsule, the posterior thalamic radiation, and the superior corona radiata. Functional connectivity analysis showed decreased negative interhemispheric coupling between contralesional and ipsilesional sensorimotor regions, and decreased positive intrahemispheric coupling among contralesional sensorimotor regions. These findings indicate that BMI reinforcing ipsilesional brain activity and enhancing proprioceptive function of the affected hand elicits reorganization of contralesional and ipsilesional somatosensory and motor-assemblies as well as afferent and efferent connection-related motor circuits that support the partial re-establishment of the original neurophysiology of the motor system even in severe chronic stroke.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.