Evidence map›Paper›PMID 31802431›Full record

ArticleJournal of physiology and biochemistry2020

Simulated air dives induce superoxide, nitric oxide, peroxynitrite, and Ca

Qiong Wang, François Guerrero, Kate Lambrechts, Aleksandra Mazur, Peter Buzzacott, Marc Belhomme, Michaël Theron

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of physiology and biochemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Trial
  2. Inert Gas Mild Pressure Action on Healthy Humans: The "IPA" Study.International journal of molecular sciences · 2024
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Qiong WangLaboratory ORPHY, European University of Bretagne, University of Brest, 6 Avenue Le Gorgeu, 29238, Brest, France.
François GuerreroLaboratory ORPHY, European University of Bretagne, University of Brest, 6 Avenue Le Gorgeu, 29238, Brest, France.
Kate LambrechtsLaboratory ORPHY, European University of Bretagne, University of Brest, 6 Avenue Le Gorgeu, 29238, Brest, France.
Aleksandra MazurLaboratory ORPHY, European University of Bretagne, University of Brest, 6 Avenue Le Gorgeu, 29238, Brest, France.
Peter BuzzacottLaboratory ORPHY, European University of Bretagne, University of Brest, 6 Avenue Le Gorgeu, 29238, Brest, France.
Marc BelhommeLaboratory ORPHY, European University of Bretagne, University of Brest, 6 Avenue Le Gorgeu, 29238, Brest, France.
Michaël TheronLaboratory ORPHY, European University of Bretagne, University of Brest, 6 Avenue Le Gorgeu, 29238, Brest, France. Michael.theron@univ-brest.fr.ORCID http://orcid.org/0000-0002-3338-5205
Université Européenne de Bretagne · FR

Funding

FP7 People: Marie-Curie Actions 264816
6 · The paper itself

Abstract

Human diving is known to induce endothelial dysfunction. The aim of this study was to decipher the mechanism of ROS production during diving through the measure of mitochondrial calcium concentration, peroxynitrite, NO°, and superoxide towards better understanding of dive-induced endothelial dysfunction. Air diving simulation using bovine arterial endothelial cells (compression rate 101 kPa/min to 808 kPa, time at depth 45 min) was performed in a system allowing real-time fluorescent measurement. During compression, the cells showed increased mitochondrial superoxide, peroxynitrite, and mitochondrial calcium, and decreased NO° concentration. MnTBAP (peroxynitrite scavenger) suppressed superoxide, recovered NO° production and promoted stronger calcium influx. Superoxide and peroxynitrite were inhibited by L-NIO (eNOS inhibitor), but were further increased by spermine-NONOate (NO° donor). L-NIO induced stronger calcium influx than spermine-NONOate or simple diving. The superoxide and peroxynitrite were also inhibited by ruthenium red (blocker of mitochondrial Ca

Indexed as

AnimalsAortaCalciumCattleCells, CulturedDivingEndothelial CellsEndothelium, VascularMitochondriaNitric OxidePeroxynitrous AcidSuperoxidesCalciumNitric OxidePeroxynitrous AcidSuperoxidesEndothelial cellMitochondrial calciumNitric oxidePeroxynitriteSCUBA divingSuperoxide

Identifiers

PMID31802431
OpenAlexW2993194087

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.