Evidence map›Paper›PMID 31802361›Full record

ReviewMolecular imaging and biology2020

In vivo Cell Tracking Using Non-invasive Imaging of Iron Oxide-Based Particles with Particular Relevance for Stem Cell-Based Treatments of Neurological and Cardiac Disease.

Joel C Glover, Markus Aswendt, Jean-Luc Boulland, Jasna Lojk, Stefan Stamenković, Pavle Andjus, Fabrizio Fiori, Mathias Hoehn, Dinko Mitrecic, Mojca Pavlin and 4 more

Erratum issuedAbstract readReview
PubMed Publisher
In one paragraph

Review in Molecular imaging and biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Machine Learning and Deep Learning Applications in Magnetic Particle Imaging.Journal of magnetic resonance imaging : JMRI · 2025
    Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
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  10. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Joel C GloverLaboratory for Neural Development and Optical Recording (NDEVOR), Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, PB 1105, Blindern, Oslo, Norway. joel.glover@medisin.uio.no.ORCID http://orcid.org/0000-0002-4621-0164
Markus Aswendt *Institut für Neurowissenschaften und Medizin, Forschungszentrum Jülich, Leo-Brandt-Str. 5, 52425, Jülich, Germany.
Jean-Luc Boulland *Laboratory for Neural Development and Optical Recording (NDEVOR), Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, PB 1105, Blindern, Oslo, Norway.
Jasna Lojk *Group for Nano and Biotechnological Applications, Faculty of Electrical Engineering, University of Ljubljana, Trzaska cesta 25, Ljubljana, Slovenia.
Stefan Stamenković *Center for Laser Microscopy, Department of Physiology and Biochemistry, Faculty of Biology, University of Belgrade, PB 52, 10001 Belgrade, Serbia.
Pavle AndjusCenter for Laser Microscopy, Department of Physiology and Biochemistry, Faculty of Biology, University of Belgrade, PB 52, 10001 Belgrade, Serbia.
Fabrizio FioriDepartment of Applied Physics, Università Politecnica delle Marche - Di.S.C.O., Via Brecce Bianche, 60131, Ancona, Italy.
Mathias HoehnInstitut für Neurowissenschaften und Medizin, Forschungszentrum Jülich, Leo-Brandt-Str. 5, 52425, Jülich, Germany.
Dinko MitrecicLaboratory for Stem Cells, Croatian Institute for Brain Research, School of Medicine, University of Zagreb, Zagreb, Croatia.
Mojca PavlinGroup for Nano and Biotechnological Applications, Faculty of Electrical Engineering, University of Ljubljana, Trzaska cesta 25, Ljubljana, Slovenia.
Stefano CavalliDepartment of Medicine and Surgery, University of Parma, Parma, Italy.
Caterina FratiDepartment of Medicine and Surgery, University of Parma, Parma, Italy.
Federico QuainiDepartment of Medicine and Surgery, University of Parma, Parma, Italy.
EU COST Action 16122 (BIONECA)

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stem cell-based therapeutics is a rapidly developing field associated with a number of clinical challenges. One such challenge lies in the implementation of methods to track stem cells and stem cell-derived cells in experimental animal models and in the living patient. Here, we provide an overview of cell tracking in the context of cardiac and neurological disease, focusing on the use of iron oxide-based particles (IOPs) visualized in vivo using magnetic resonance imaging (MRI). We discuss the types of IOPs available for such tracking, their advantages and limitations, approaches for labeling cells with IOPs, biological interactions and effects of IOPs at the molecular and cellular levels, and MRI-based and associated approaches for in vivo and histological visualization. We conclude with reviews of the literature on IOP-based cell tracking in cardiac and neurological disease, covering both preclinical and clinical studies.

Indexed as

Cell TrackingMolecular ImagingAnimalsFerric CompoundsHeart DiseasesHumansNervous System DiseasesStem CellsFerric Compoundsferric oxideCardiomyocytesIron oxideMicro-CTMIONMPIMPIOMRINeural progenitor cellsSPIOStem cellUSPIO

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.