ArticleBehavior genetics2020
Familial Influences on Neuroticism and Education in the UK Biobank.
Article in Behavior genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Article
- Genetic mechanisms, brain structures, and peripheral biomarkers mediate the relationship between physical frailty and neuropsychiatric disorders.Journal of advanced research · 2026Article
- Machine learning-assisted optimization of dietary intervention against dementia risk.Nature human behaviour · 2025Article
- Article
- Striking Departures from Polygenic Architecture in the Tails of Complex Traits.bioRxiv : the preprint server for biology · 2024Article
- A Two-Sample Mendelian Randomization Study of Neuroticism and Sleep Bruxism.Journal of dental research · 2024Article
- Article
- Multimodal Data Integration Improves Disease Risk Prediction in the UK Biobank.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2024Article
- Genetic basis of STEM occupational choice and regional economic performance: a UK biobank genome-wide association study.Human genomics · 2023Article
- Childhood trajectories of internalising and externalising problems associated with a polygenic risk score for neuroticism in a UK birth cohort study.JCPP advances · 2023Article
- Why we need families in genomic research on developmental psychopathology.JCPP advances · 2023Article
- Association of circadian rhythms with brain disorder incidents: a prospective cohort study of 72242 participants.Translational psychiatry · 2022Article
- A Moderated Mediation Model of the Relationship between Family Dynamics and Sleep Quality in College Students: The Role of Big Five Personality and Only-Child Status.International journal of environmental research and public health · 2022Article
- Association Between Medication-Taking and Refractive Error in a Large General Population-Based Cohort.Investigative ophthalmology & visual science · 2021Article
- Spatial distribution and cognitive impact of cerebrovascular risk-related white matter hyperintensities.NeuroImage. Clinical · 2020Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Genome-wide studies often exclude family members, even though they are a valuable source of information. We identified parent-offspring pairs, siblings and couples in the UK Biobank and implemented a family-based DNA-derived heritability method to capture additional genetic effects and multiple sources of environmental influence on neuroticism and years of education. Compared to estimates from unrelated individuals, total heritability increased from 10 to 27% and from 17 to 56% for neuroticism and education respectively by including family-based genetic effects. We detected no family environmental influences on neuroticism. The couple similarity variance component explained 35% of the variation in years of education, probably reflecting assortative mating. Overall, our genetic and environmental estimates closely replicate previous findings from an independent sample. However, more research is required to dissect contributions to the additional heritability by rare and structural genetic effects, assortative mating, and residual environmental confounding. The latter is especially relevant for years of education, a highly socially contingent variable, for which our heritability estimate is at the upper end of twin estimates in the literature. Family-based genetic effects could be harnessed to improve polygenic prediction.
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