ArticleBiomechanics and modeling in mechanobiology2020
The impact of wall thickness and curvature on wall stress in patient-specific electromechanical models of the left atrium.
Article in Biomechanics and modeling in mechanobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 53 citations in OpenAlex.
- Three-Dimensional Left Atrial Geometry in Atrial Fibrillation: Imaging Biomarkers, Substrate Phenotyping, and Ablation Outcome Prediction.Diagnostics (Basel, Switzerland) · 2026Review
- Early activation of Virchow's triad in feline hypertrophic cardiomyopathy: beyond spontaneous echo contrast and insights into translational thromboembolism.Frontiers in veterinary science · 2026Review
- Systematic computational assessment of atrial function impairment due to fibrotic remodeling in electromechanical properties.PLoS computational biology · 2025Article
- Regional heterogeneity in left atrial stiffness impacts passive deformation in a cohort of patient-specific models.PLoS computational biology · 2025Article
- Computational modelling of the impact of anatomical changes on ECGs in left ventricular hypertrophy.The Journal of physiology · 2025Article
- The left atrium in heart failure with preserved ejection fraction: What we know and what we do not know.Heart rhythm O2 · 2025Review
- Defining myocardial fiber bundle architecture in atrial digital twins.Computers in biology and medicine · 2025Article
- Multiphysics simulations reveal haemodynamic impacts of patient-derived fibrosis-related changes in left atrial tissue mechanics.The Journal of physiology · 2024Article
- Article
- Simulating cardiac fluid dynamics in the human heart.PNAS nexus · 2024Article
- Left Atrial Roof Enlargement Is a Distinct Feature of Heart Failure With Preserved Ejection Fraction.Circulation. Cardiovascular imaging · 2024Article
- A Semi-automatic Pipeline for Generation of Large Cohorts of Four-Chamber Heart Meshes.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Advancing clinical translation of cardiac biomechanics models: a comprehensive review, applications and future pathways.Frontiers in physics · 2023Article
- Left atrial sphericity in relation to atrial strain and strain rate in atrial fibrillation patients.The international journal of cardiovascular imaging · 2023Article
- The Impact of Standard Ablation Strategies for Atrial Fibrillation on Cardiovascular Performance in a Four-Chamber Heart Model.Cardiovascular engineering and technology · 2023Article
- The physics of heart rhythm disorders.Physics reports · 2022Article
- Robust and efficient fixed-point algorithm for the inverse elastostatic problem to identify myocardial passive material parameters and the unloaded reference configuration.Journal of computational physics · 2022Article
- Linking statistical shape models and simulated function in the healthy adult human heart.PLoS computational biology · 2021Article
- Left Atrial Wall Stress and the Long-Term Outcome of Catheter Ablation of Atrial Fibrillation: An Artificial Intelligence-Based Prediction of Atrial Wall Stress.Frontiers in physiology · 2021Article
- A survey of pathways for mechano-electric coupling in the atria.Progress in biophysics and molecular biology · 2021Article
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Authors and funding
10 authors at 4 institutions in 3 countries.
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Abstract
The left atrium (LA) has a complex anatomy with heterogeneous wall thickness and curvature. The anatomy plays an important role in determining local wall stress; however, the relative contribution of wall thickness and curvature in determining wall stress in the LA is unknown. We have developed electromechanical finite element (FE) models of the LA using patient-specific anatomical FE meshes with rule-based myofiber directions. The models of the LA were passively inflated to 10mmHg followed by simulation of the contraction phase of the atrial cardiac cycle. The FE models predicted maximum LA volumes of 156.5 mL, 99.3 mL and 83.4 mL and ejection fractions of 36.9%, 32.0% and 25.2%. The median wall thickness in the 3 cases was calculated as [Formula: see text] mm, [Formula: see text] mm, and [Formula: see text] mm. The median curvature was determined as [Formula: see text] [Formula: see text], [Formula: see text], and [Formula: see text]. Following passive inflation, the correlation of wall stress with the inverse of wall thickness and curvature was 0.55-0.62 and 0.20-0.25, respectively. At peak contraction, the correlation of wall stress with the inverse of wall thickness and curvature was 0.38-0.44 and 0.16-0.34, respectively. In the LA, the 1st principal Cauchy stress is more dependent on wall thickness than curvature during passive inflation and both correlations decrease during active contraction. This emphasizes the importance of including the heterogeneous wall thickness in electromechanical FE simulations of the LA. Overall, simulation results and sensitivity analyses show that in complex atrial anatomy it is unlikely that a simple anatomical-based law can be used to estimate local wall stress, demonstrating the importance of FE analyses.
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