Evidence map›Paper›PMID 31802280›Full record

ArticleJournal of materials science. Materials in medicine2019

Stretchable collagen-coated polyurethane-urea hydrogel seeded with bladder smooth muscle cells for urethral defect repair in a rabbit model.

Chengyuan Wang, Chunyang Chen, Mingyu Guo, Bin Li, Fengxuan Han, Weiguo Chen

Abstract read
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In one paragraph

Article in Journal of materials science. Materials in medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Chengyuan WangDepartment of Urology, The First Affiliated Hospital, Soochow University, Suzhou, Jiangsu, 215006, China.
Chunyang ChenDepartment of Urology, The First Affiliated Hospital, Soochow University, Suzhou, Jiangsu, 215006, China.
Mingyu GuoOrthopaedic Institute, College of Chemistry, Chemical Engineering and Material Science, Soochow University, Suzhou, Jiangsu, 215006, China.
Bin LiOrthopaedic Institute, College of Chemistry, Chemical Engineering and Material Science, Soochow University, Suzhou, Jiangsu, 215006, China. binli@suda.edu.cn.
Fengxuan HanOrthopaedic Institute, College of Chemistry, Chemical Engineering and Material Science, Soochow University, Suzhou, Jiangsu, 215006, China. fxhan@suda.edu.cn.ORCID http://orcid.org/0000-0003-3301-6888
Weiguo ChenDepartment of Urology, The First Affiliated Hospital, Soochow University, Suzhou, Jiangsu, 215006, China. cwgms123@163.com.
Soochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The major challenge to treat the clinical adverse effects of long-segment urethra is in achieving viable tissue substitution. The substituted construct's properties-such as its resilience, contraction, and ability to minimize scar-stenosis formation should be considered. In the present work, a unique polyurethane-urea (PUU) fibrous membrane is fabricated by electrospinning. Then PUU was coated by collagen and formed the elasticity hydrogel after immersed in collagen solution. Meanwhile, the cPUU hydrogel exhibited a fibrous microstructure. This cPUU hydrogel had outstanding stretching property with 404 ± 40% elongation at break compared with traditional hydrogels, which satisfied the requirement of urethra. The cPUU hydrogel also supported the adhesion and growth of bladder smooth-muscle cells (BSMCs) in natural state cell morphology. Urethral defects in New Zealand male rabbits were repaired with cPUU seeded with BSMCs in vivo. After three months, more smooth-surface area of reconstructed urethral tissues was observed in the cPUU hydrogel-BMSCs groups compared with that of the control group. The luminal patency and the incidence of complications-including calculus formation, urinary fistula, and urethral-stricture occurrence were significantly lower in the cPUU group compared with that of the control group. Hence, cPUU fibrous hydrogels are promising scaffolds for application in urological tissue engineering.

Indexed as

AnimalsBiocompatible MaterialsCollagenHydrogelsMaleMaterials TestingMyocytes, Smooth MusclePolyurethanesRabbitsTissue EngineeringTissue ScaffoldsUreaUrethral DiseasesUrinary BladderBiocompatible MaterialsCollagenHydrogelsPolyurethanesUrea

Identifiers

PMID31802280
OpenAlexW2993515851

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.