ArticleJournal of neural transmission (Vienna, Austria : 1996)2020
Caregiver burden and health-related quality of life in idiopathic dystonia patients under botulinum toxin treatment: a cross-sectional study.
Article in Journal of neural transmission (Vienna, Austria : 1996), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy and Safety of Botulinum Toxin vs. Placebo in Depression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Frontiers in psychiatry · 2020Pooled it
- Caring for persons with X-linked dystonia-parkinsonism in Metro Manila: insights into the burden of family caregivers.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Impact of X-linked dystonia-parkinsonism on caregiver strain, anxiety and depression.BMJ neurology open · 2026Article
- Predictors of Loneliness in Parkinson's Disease and Craniocervical Dystonia.Movement disorders clinical practice · 2025Article
- Patient Burden in Dystonia Diagnosis and Botulinum Toxin Treatment: A Nationwide Survey in Turkey.Brain and behavior · 2025Article
- The Associations Between Depression, Subjective Sleep Quality, and Health-Related Quality of Life in Patients with Meige Syndrome: A Cross-Sectional Study.Nature and science of sleep · 2025Article
- Caregiver Burden in Movement Disorders and Neurodegenerative Diseases: Editorial.Brain sciences · 2022Article
- Hold that pose: capturing cervical dystonia's head deviation severity from video.Annals of clinical and translational neurology · 2022Article
- Neuropsychiatric Symptoms in Parkinson's Disease Patients Are Associated with Reduced Health-Related Quality of Life and Increased Caregiver Burden.Brain sciences · 2022Article
- Emotional well-being and pain could be a greater determinant of quality of life compared to motor severity in cervical dystonia.Journal of neural transmission (Vienna, Austria : 1996) · 2021Observational
- One Year Trajectory of Caregiver Burden in Parkinson's Disease and Analysis of Gender-Specific Aspects.Brain sciences · 2021Article
- Validation of the Parkinson's Disease Caregiver Burden Questionnaire in Progressive Supranuclear Palsy.Parkinson's disease · 2021Article
- Perspective of an International Online Patient and Caregiver Community on the Burden of Spasticity and Impact of Botulinum Neurotoxin Therapy: Survey Study.JMIR public health and surveillance · 2020Article
- Dysphagia in cervical dystonia patients receiving optimised botulinum toxin therapy: a single-center retrospective cohort study.Journal of neural transmission (Vienna, Austria : 1996) · 2020Article
- Alexithymia Is Associated with Reduced Quality of Life and Increased Caregiver Burden in Parkinson's Disease.Brain sciences · 2020Article
- Mindfulness and Psychological Flexibility are Inversely Associated with Caregiver Burden in Parkinson's Disease.Brain sciences · 2020Article
- Parkinson's Disease Caregiver Strain in Singapore.Frontiers in neurology · 2020Article
- Association of Motor and Cognitive Symptoms with Health-Related Quality of Life and Caregiver Burden in a German Cohort of Advanced Parkinson's Disease Patients.Parkinson's disease · 2020Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dystonia is a chronic movement disorder that is associated with a reduction in health-related quality of life (HR-QoL) and restriction of activities of daily living. Botulinum neurotoxin (BT) improves disease-specific HR-QoL by reducing abnormal movements, postures, and pain. We examined the burden of the corresponding primary caregiver as a potential important factor for disease management and HR-QoL of dystonia patients under treatment with BT. 114 patients with focal, segmental, or generalized dystonia were recruited, together with 93 corresponding caregivers, whose burden was investigated using the Caregiver Burden Inventory. In addition, all participants were assessed for cognitive impairment, depression, anxiety, alexithymia, and HR-QoL. Only a small proportion of caregivers suffered from caregiver burden. Despite BT therapy, patients' HR-QoL was decreased compared to the age-matched general German population. Psychological symptoms, notably anxiety, and depression correlated significantly with reduced HR-QoL. Our data imply that caregiver burden emerged to be an issue in subgroups of dystonia patients. Furthermore, HR-QoL of dystonia patients is reduced even under optimized BT treatment in a specialized center.
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