Evidence map›Paper›PMID 31802219›Full record

ReviewJournal of neurology2021

The motor prodromes of parkinson's disease: from bedside observation to large-scale application.

C Simonet, A Schrag, A J Lees, A J Noyce

Open access · hybridAbstract readReview
In one paragraph

Review in Journal of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 53 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. The Role of Immune Dysfunction in Parkinson's Disease Development.International journal of molecular sciences · 2023
    Review
  13. The Views of Patients with Isolated Rapid Eye Movement Sleep Behavior Disorder on Risk Disclosure.Movement disorders : official journal of the Movement Disorder Society · 2023
    Article
  14. Article
  15. Article
  16. Review
  17. Disease modification in Parkinsonism: obstacles and ways forward.Journal of neural transmission (Vienna, Austria : 1996) · 2022
    Review
  18. Article
  19. Article
  20. Detecting Effect of Levodopa in Parkinson's Disease Patients Using Sustained Phonemes.IEEE journal of translational engineering in health and medicine · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

C SimonetPreventive Neurology Unit, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK.
A SchragDepartment of Clinical and Movement Neurosciences, Institute of Neurology, University College London, London, UK.
A J LeesReta Lila Weston Institute of Neurological Studies, University College London, London, UK.
A J NoycePreventive Neurology Unit, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK. a.noyce@qmul.ac.uk.ORCID http://orcid.org/0000-0003-3027-5497
Queen Mary University of London · GBUniversity College London · GB

Funding

Barts Charity MGU0364Parkinson's UK F-1201Parkinson's UK G-1606
6 · The paper itself

Abstract

There is sufficient evidence that the pathological process that causes Parkinson's disease begins years before the clinical diagnosis is made. Over the last 15 years, there has been much interest in the existence of a prodrome in some patients, with a particular focus on non-motor symptoms such as reduced sense of smell, REM-sleep disorder, depression, and constipation. Given that the diagnostic criteria for Parkinson's disease depends on the presence of bradykinesia, it is somewhat surprising that there has been much less research into the possibility of subtle motor dysfunction as a pre-diagnostic pointer. This review will focus on early motor features and provide some advice on how to detect and measure them.

Indexed as

Parkinson DiseaseREM Sleep Behavior DisorderConstipationHumansHypokinesiaParkinson’s diseasePopulation studiesProdromal phaseQuantitative motor analysisSubtle motor signs

Identifiers

PMID31802219
PMCPMC8179909
OpenAlexW2994086920

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.