Evidence map›Paper›PMID 31802210›Full record

ReviewRheumatology international2020

The effects of exercise on cardiovascular disease risk factors and cardiovascular physiology in rheumatoid arthritis.

George S Metsios, R H Moe, M van der Esch, J J C S Veldhuijzen van Zanten, S A M Fenton, Y Koutedakis, P Vitalis, N Kennedy, N Brodin, C Bostrom and 9 more

Registry-linked trialOpen access · greenAbstract readReview
PubMed Publisher
In one paragraph

Review in Rheumatology international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07558187 (Assessment of Lifestyle Parameters and Biomarkers of Biochemistry and Physiology to Address Health Inequalities), which is not on this map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07558187 recruitingnot on this mapstarted 2026, after this paper: background citation

Assessment of Lifestyle Parameters and Biomarkers of Biochemistry and Physiology to Address Health Inequalities: An Exploratory Cohort Study

TypeobservationalSponsorUniversity of ThessalyRan2026 to 2028Enrolled2,000ConditionsNon-communicable Diseases (NCD), Addiction to Opioids, Incarceration, Opioid-use Disorders
3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
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  5. Active Video Gaming and Obesity in Children 6-12 Years Old: A Systematic Review.Journal of functional morphology and kinesiology · 2026
    Review
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  19. Ethical issues experienced by persons with rheumatoid arthritis in a wearable-enabled physical activity intervention study.Health expectations : an international journal of public participation in health care and health policy · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 14 institutions in 8 countries.

George S MetsiosFaculty of Education, Health and Wellbeing, University of Wolverhampton, Gorway Road, Walsall Campus, Walsall, WS13BD, UK. g.metsios@wlv.ac.uk.ORCID http://orcid.org/0000-0001-5359-0436
R H MoeDepartment of Rheumatology, National Resource Centre for Rehabilitation in Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.ORCID http://orcid.org/0000-0001-7601-5346
M van der EschACHIEVE-Center of Applied Research, Faculty of Health, Reade, Center for Rehabilitation and Rheumatology/Amsterdam Rehabilitation Research Center, Amsterdam University of Applied Sciences, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-0485-8560
J J C S Veldhuijzen van ZantenSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK.ORCID http://orcid.org/0000-0001-8422-9512
S A M FentonSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK.ORCID http://orcid.org/0000-0002-3732-1348
Y KoutedakisSchool of Physical Education and Sport Science, University of Thessaly, Volos, Greece.ORCID http://orcid.org/0000-0002-7065-9447
P VitalisFaculty of Education, Health and Wellbeing, University of Wolverhampton, Gorway Road, Walsall Campus, Walsall, WS13BD, UK.ORCID http://orcid.org/0000-0002-7799-7924
N KennedySchool of Allied Health, Faculty of Education and Health Sciences and Health Research Institute, University of Limerick, Limerick, Ireland.ORCID http://orcid.org/0000-0001-6047-1240
N BrodinDepartment of Neurobiology, Care Sciences and Society, Division of Physiotherapy, Karolinska Institutet, Huddinge, Sweden.ORCID http://orcid.org/0000-0002-3589-664X
C BostromDepartment of Neurobiology, Care Sciences and Society, Division of Physiotherapy, Karolinska Institutet, Huddinge, Sweden.ORCID http://orcid.org/0000-0002-2506-687X
T W SwinnenDivision of Rheumatology, University Hospitals Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0002-5289-1023
K TzikaFaculty of Education, Health and Wellbeing, University of Wolverhampton, Gorway Road, Walsall Campus, Walsall, WS13BD, UK.ORCID http://orcid.org/0000-0002-0919-0352
K NiedermannSchool of Health Professions, Institute of Physiotherapy, Zurich University of Applied Sciences, Winterthur, Switzerland.
E NikiphorouDepartment of Academic Rheumatology, King's College London, London, UK.ORCID http://orcid.org/0000-0001-6847-3726
G E FragoulisInstitute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK.ORCID http://orcid.org/0000-0003-4932-7023
T P V M VlielandDepartment of Orthopaedics, Rehabilitation and Physical Therapy, Leiden University Medical Center, Leiden, The Netherlands.ORCID http://orcid.org/0000-0001-6322-3859
C H M Van den EndeDepartment of Rheumatology, Sint Maartenskliniek, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0002-4352-2824
George D KitasDepartment of Rheumatology, Russells Hall Hospital, Dudley Group NHS Foundation Trust, Dudley, UK.ORCID http://orcid.org/0000-0002-0828-6176
IMPACT-RMD Consortium
University of Wolverhampton · GBKarolinska Institutet · SEUniversity of Birmingham · GBDiakonhjemmet Hospital · NOKing's College London · GBKU Leuven · BELeiden University Medical Center · NLReade · NLRussells Hall Hospital · GBSint Maartenskliniek · NLUniversity of Glasgow · GBUniversity of Limerick · IEUniversity of Thessaly · GRZHAW Zurich University of Applied Sciences · CH

Funding

European League Against Rheumatism HPR043: : IMplementation of Physical Activity into routine Clinical pracTice in Rheumatic Musculoskeletal Disease: The IMPACT-RMD study
6 · The paper itself

Abstract

Cardiovascular disease (CVD) morbidity and mortality is highly prevalent in patients with rheumatoid arthritis (RA) with debilitating effects for the individual as well as significant healthcare impact. Current evidence demonstrates that engaging in aerobic and resistance exercise (i.e. structured physical activity) can significantly improve patient-reported and clinical index-assessed outcomes in RA. In addition to this, engagement in exercise programmes improves, in a dose-dependent manner, the risk of developing CVD as well as CVD symptoms and outcomes. The present narrative review uses evidence from systematic reviews and meta-analyses as well as controlled trials, to synthesize the current state-of-the-art on the potential effects of aerobic and resistance exercise on CVD risk factors as well as on cardiac and vascular function and structure in people with RA. Where there is a lack of evidence in RA to explain potential mechanisms, relevant studies from the general population are also discussed and linked to RA.

Indexed as

Cardiovascular Physiological PhenomenaArthritis, RheumatoidCardiovascular DiseasesExerciseHumansRisk FactorsAutoimmune diseaseCardiovascular diseaseExerciseInflammationNon-communicable diseasePhysical activityRehabilitationRheumatoid arthritis

Identifiers

PMID31802210
OpenAlexW2993989417

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.