Evidence map›Paper›PMID 31802206›Full record

SynthesisWorld journal of urology2020

The use of mirabegron in neurogenic bladder: a systematic review.

Elie El Helou, Chris Labaki, Roy Chebel, Jeanine El Helou, Georges Abi Tayeh, Georges Jalkh, Elie Nemr

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in World journal of urology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
3.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Neurogenic Bladder in Children with Myelomeningocele.Diseases (Basel, Switzerland) · 2025
    Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Elie El HelouDepartment of Urology, Faculty of Medicine, Saint Joseph University, Beirut, Lebanon. elie.helou@usj.edu.lb.
Chris LabakiDepartment of Urology, Faculty of Medicine, Saint Joseph University, Beirut, Lebanon.
Roy ChebelDepartment of Urology, Faculty of Medicine, Saint Joseph University, Beirut, Lebanon.
Jeanine El HelouDepartment of Neurology, Faculty of Medicine, Saint Joseph University, Beirut, Lebanon.
Georges Abi TayehDepartment of Urology, Faculty of Medicine, Saint Joseph University, Beirut, Lebanon.
Georges JalkhDepartment of Neurology, Faculty of Medicine, Saint Joseph University, Beirut, Lebanon.
Elie NemrDepartment of Urology, Faculty of Medicine, Saint Joseph University, Beirut, Lebanon.
Saint Joseph University · LB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the use of mirabegron in patients with neurogenic bladder.

methodsA systematic review of the literature was conducted using four databases (Medline via PubMed, Scopus, Cochrane, and EMBASE). Articles evaluating mirabegron in neurogenic bladder patients were collected, and assessment of the drug's efficacy was reviewed according to clinical and urodynamic parameters.

resultsSeven studies were selected and a total of 302 patients with NB were evaluated, ranging from 15 to 66 patients per study. All of the patients had received antimuscarinics as a previous treatment modality. Mirabegron was used as a second-line treatment after antimuscarinics lacked efficacy or caused adverse effects. The duration of the treatments ranged from 4 to 12 weeks. Reported in two studies each, bladder compliance and maximal cystometric capacity were the most commonly improved urodynamic parameters. In the majority of the studies, positive outcomes were reported for clinical scores. Additionally, analysis of the IPSS subscores revealed an improvement of storage symptoms as opposed to voiding symptoms. In all of the studies, mirabegron was well tolerated.

conclusionMirabegron appears to be an effective treatment in the management of neurogenic bladder unresponsive to antimuscarinics, particularly in patients presenting with storage symptoms. There is still no evidence concerning the use of mirabegron as a first-line therapy for neurogenic bladder.

Indexed as

AcetanilidesAdrenergic beta-3 Receptor AgonistsHumansThiazolesTreatment OutcomeUrinary Bladder, NeurogenicAcetanilidesAdrenergic beta-3 Receptor AgonistsmirabegronThiazolesAntimuscarinicsMirabegronNeurogenic bladderUrodynamics

Identifiers

PMID31802206
OpenAlexW2993941815

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.