ArticleNature2019
The molecular landscape of ETMR at diagnosis and relapse.
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In one paragraph
Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed, 1 pooled it
5.8field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
81 citing papers in PubMed, 1 synthesis or guideline pooled it, 142 citations in OpenAlex.
- Quality-controlled R-loop meta-analysis reveals the characteristics of R-loop consensus regions.Nucleic acids research · 2022Pooled it
- Molecular classification and outcome of children with rare CNS embryonal tumors: results from St. Jude Children's Research Hospital including the multi-center SJYC07 and SJMB03 clinical trials.Acta neuropathologica · 2022Trial
- Timing of radiotherapy and autologous stem cell transplantation in embryonal tumor with multilayered rosettes: a critical narrative review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Review
- Recurrent C19MC-altered embryonal tumors with multilayered rosettes: outcomes of stereotactic radiosurgery.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Article
- Multi-omics dissection of R-loop dynamics in tumorigenesis: From transcription-replication conflict to therapeutic targets.Molecular therapy. Oncology · 2026Review
- Conception-calibrated male pediatric tumor mitotic clocks.Communications biology · 2026Article
- Cerebrospinal Fluid in Pediatric Neuro-Oncology: Molecular Diagnosis, Disease Monitoring, and Clinical Translation.International journal of molecular sciences · 2026Review
- Ovarian central nervous system-type tumors: integrated neuropathological and methylation-based classification reveals site-related features.Acta neuropathologica communications · 2026Article
- The future of targeted therapies for pediatric central nervous system tumors.Neuro-oncology advances · 2026Review
- Patient-derived pediatric brain tumor orthotopic xenografts and tumor organoids faithfully recapitulate primary tumors.Science advances · 2026Article
- Extracranial teratoid medulloepithelioma: A pelvic observation with genetic and epigenetic findings.Virchows Archiv : an international journal of pathology · 2026Article
- Freiburg Neuropathology Case Conference: A 2-Year-Old Child with Progressive Headache, Nausea, and Personality Change.Clinical neuroradiology · 2026Article
- Clinicopathological and prognostic insights into Embryonal Tumors with Multilayered Rosettes (ETMRs).Diagnostic pathology · 2026Article
- How is rosette formation in brain tumours linked with cerebrospinal fluid spread?Brain tumor pathology · 2026Review
- The Mutational Epidemiology of Childhood Cancer.Clinical chemistry · 2025Review
- YAP1::MAML2 fusion, a newly identified genetic anomaly in a posterior fossa infant tumor, associated with the methylation class "embryonal tumor with multilayered rosettes, non-C19MC-altered" in the Heidelberg central nervous system tumor classifier and "embryonal tumor with multilayered rosettes-DICER" in the NIH classifier.Acta neuropathologica communications · 2025Article
- Rare and aggressive: A case of embryonal tumor with multilayered rosettes (ETMR) in a young child.Radiology case reports · 2025Article
- Senataxin regulates cisplatin resistance through an R-loop-mediated mechanism in HPV-associated head and neck cancer.iScience · 2025Article
- Possible role of human ribonuclease dicer in the regulation of R loops.FEBS open bio · 2025Review
- Outcomes following radiation therapy for embryonal tumor with multilayered rosettes (ETMR): results from the Pediatric Proton/Photon Consortium Registry (PPCR).Journal of neuro-oncology · 2025Article
21 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
65 authors at 20 institutions in 13 countries.
Sander LamboHopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
Susanne N GröbnerHopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
Tobias RauschEuropean Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany.
Sebastian M WaszakEuropean Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany.
Christin SchmidtHopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
Aparna GorthiDepartment of Cell Systems and Anatomy, University of Texas Health at San Antonio, San Antonio, TX, USA.
July Carolina RomeroDepartment of Cell Systems and Anatomy, University of Texas Health at San Antonio, San Antonio, TX, USA.
Monika MauermannHopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
Sebastian BrabetzHopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
Sonja KrausertHopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
Ivo BuchhalterOmics IT and Data Management Core Facility, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Jan KosterDepartment of Oncogenomics, Academic Medical Center, Amsterdam, The Netherlands.
Danny A ZwijnenburgDepartment of Oncogenomics, Academic Medical Center, Amsterdam, The Netherlands.
Martin SillHopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
Jens-Martin HübnerHopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
Norman MackHopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
Benjamin SchwalmHopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
Marina RyzhovaDepartment of Neuropathology, NN Burdenko Neurosurgical Institute, Moscow, Russia.
Volker HovestadtDivision of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Simon Papillon-CavanaghDepartment of Pediatrics, McGill University Health Center, McGill University, Montreal, Quebec, Canada.
Jennifer A ChanDepartment of Pathology and Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada.
Pablo LandgrafDepartment of Pediatrics, Pediatric Oncology and Hematology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Ben HoDivision of Hematology/Oncology Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
Till MildeHopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
Olaf WittHopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
Jonas EckerHopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
Felix SahmHopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
David SumerauerDepartment of Pediatric Hematology and Oncology, University Hospital Motol, Prague, Czech Republic.
David W EllisonDepartment of Pathology, St Jude Children's Research Hospital, Memphis, TN, USA.
Brent A OrrDepartment of Pathology, St Jude Children's Research Hospital, Memphis, TN, USA.
Anna DarabiDepartment of Clinical Sciences Lund, Section of Neurosurgery, Faculty of Medicine, Lund University, Lund, Sweden.
Christine HaberlerInstitute of Neurology, Medical University of Vienna, Vienna, Austria.
Dominique Figarella-BrangerAix-Marseille University, Neurophysiopathology Institute (INP), CNRS, Marseille, France.
Pieter WesselingPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Jens SchittenhelmDepartment of Neuropathology, Institute of Pathology and Neuropathology, University Hospital of Tübingen, Tübingen, Germany.
Marc RemkeGerman Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Michael D TaylorDivision of Neurosurgery, Arthur and Sonia Labatt Brain Tumor Research Center, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
Maria J Gil-da-CostaPediatric Hematology and Oncology Division, University Hospital São João Alameda Hernani Monteiro, Porto, Portugal.
Maria ŁastowskaDepartment of Pathology, Children's Memorial Health Institute, Warsaw, Poland.
Wiesława GrajkowskaDepartment of Pathology, Children's Memorial Health Institute, Warsaw, Poland.
Martin HasselblattInstitute of Neuropathology, University Hospital Münster, Münster, Germany.
Peter Hauser2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary.
Torsten PietschInstitute of Neuropathology, Brain Tumor Reference Center of the German Society of Neuropathology and Neuroanatomy, University of Bonn Medical Center, Bonn, Germany.
Emmanuelle Uro-CosteDepartment of Pathology, Toulouse University Hospital, Toulouse, France.
Franck BourdeautINSERM U830, Laboratory of Translational Research in Pediatric Oncology, SIREDO Pediatric Oncology Center, Paris Sciences Lettres Research University, Curie Institute, Paris, France.
Julien Masliah-PlanchonPediatric Oncology Department, SIREDO Pediatric Oncology Centre, Curie Institute, Paris, France.
Valérie RigauDepartment of Pathology, Montpellier University Medical Center, Montpellier, France.
Sanda AlexandrescuDepartment of Pathology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Stephan WolfGenomics and Proteomics Core Facility, High Throughput Sequencing Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Xiao-Nan LiBrain Tumor Program, Texas Children's Cancer Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Ulrich SchüllerInstitute of Neuropathology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany.
Matija SnuderlDepartment of Pathology, NYU Langone Health, New York, NY, USA.
Matthias A KarajannisDivision of Pediatric Hematology/Oncology, NYU Langone Medical Center, The Stephen D. Hassenfeld Children's Center for Cancer and Blood Disorders, New York, NY, USA.
Felice GiangasperoDepartment of Radiological, Oncological and Anatomopathological Sciences, Sapienza University of Rome, Rome, Italy.
Nada JabadoDepartment of Pediatrics, McGill University Health Center, McGill University, Montreal, Quebec, Canada.
Andreas von DeimlingHopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
David T W JonesHopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
Jan O KorbelEuropean Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany.
Katja von HoffDepartment of Pediatric Oncology/Hematology, Charité University Medicine, Berlin, Germany.
Peter LichterGerman Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Annie HuangDivision of Hematology/Oncology Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
Alexander J R BishopDepartment of Cell Systems and Anatomy, University of Texas Health at San Antonio, San Antonio, TX, USA.
Stefan M PfisterHopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
Andrey KorshunovDepartment of Neuropathology, Heidelberg University Hospital, Heidelberg, Germany.
Marcel KoolHopp Children's Cancer Center (KiTZ), Heidelberg, Germany. m.kool@dkfz.de.
German Cancer Research Center · DEHopp Children's Cancer Center Heidelberg · DEHeidelberg University · DEEuropean Molecular Biology Laboratory · DEAcademic Medical Center · NLChildren's Memorial Health Institute · PLHospital for Sick Children · CAMcGill University · CANYU Langone Health · USSt. Jude Children's Research Hospital · USAmsterdam University Medical Centers · NLAssistance Publique Hôpitaux de Marseille · FRBoston Children's Hospital · USBurdenko Neurosurgery Institute · RUHospital de São João · PTInserm · FRIstituto Neurologico Mediterraneo · ITLife & Brain (Germany) · DELund University · SELurie Children's Hospital · US
Funding
TISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Lei Zheng · 1991 to 2026
$59.1MCancer Biology Training ProgramT32CA148724 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Pei Wang, Feng-Chun Yang · 2011 to 2026
$3.3MNRSA Training Core (TL1)TL1TR002647 · NCATS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CHUN, YONG-HEE PATRICIA, FREI, CHRISTOPHER R. · 2018 to 2022
$1.8MImproving etoposide treatment of Ewing's sarcomaR01CA152063 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI BISHOP, ALEXANDER JAMES · 2011 to 2015
$1.5MComparing and contrasting the biology of damage survival at a genomic levelR15ES019128 · NIEHS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI BISHOP, ALEXANDER JAMES · 2010 to 2010
$446kA screen for damage response genes using recombinationK22ES012264 · NIEHS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI BISHOP, ALEXANDER JAMES · 2004 to 2006
$321kNCATS NIH HHS TL1 TR002647NCI NIH HHS P30 CA054174NCI NIH HHS R01 CA152063NCI NIH HHS T32 CA148724NIEHS NIH HHS K22 ES012264NIEHS NIH HHS R15 ES019128
Abstract
Embryonal tumours with multilayered rosettes (ETMRs) are aggressive paediatric embryonal brain tumours with a universally poor prognosis
Indexed as
DEAD-box RNA HelicasesDNA Topoisomerases, Type IHumansMicroRNAsMutationNeoplasms, Germ Cell and EmbryonalPoly(ADP-ribose) Polymerase InhibitorsPoly(ADP-ribose) PolymerasesPolymorphism, Single NucleotideRecurrenceRibonuclease IIIRNA, Long NoncodingDEAD-box RNA HelicasesDICER1 protein, humanDNA Topoisomerases, Type IMicroRNAsMIR17HG, humanPoly(ADP-ribose) Polymerase InhibitorsPoly(ADP-ribose) PolymerasesRibonuclease IIIRNA, Long NoncodingTOP1 protein, human
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.