Evidence map›Paper›PMID 31801966›Full record

ReviewMolecular psychiatry2020

Neuroplasticity in cognitive and psychological mechanisms of depression: an integrative model.

Rebecca B Price, Ronald Duman

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecular psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 360 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
360citing papers in PubMed, 6 pooled it
29.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

360 citing papers in PubMed, 6 syntheses or guidelines pooled it, 662 citations in OpenAlex.

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300 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Rebecca B PriceDepartments of Psychiatry and Psychology, University of Pittsburgh, Pittsburgh, PA, USA. rebecca.price@stanfordalumni.org.
Ronald DumanDepartment of Psychiatry, Yale University, New Haven, CT, USA.
University of Pittsburgh · USYale University · US

Funding

Testing a Synergistic, Neuroplasticity-Based Intervention for Depressive NeurocognitionR01MH113857 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PRICE, REBECCA · 2017 to 2021
$2.4M
NIMH NIH HHS R01 MH113857
6 · The paper itself

Abstract

Chronic stress and depressive-like behaviors in basic neuroscience research have been associated with impairments of neuroplasticity, such as neuronal atrophy and synaptic loss in the medial prefrontal cortex (mPFC) and hippocampus. The current review presents a novel integrative model of neuroplasticity as a multi-domain neurobiological, cognitive, and psychological construct relevant in depression and other related disorders of negative affect (e.g., anxiety). We delineate a working conceptual model in which synaptic plasticity deficits described in animal models are integrated and conceptually linked with human patient findings from cognitive science and clinical psychology. We review relevant reports including neuroimaging findings (e.g., decreased functional connectivity in prefrontal-limbic circuits), cognitive deficits (e.g., executive function and memory impairments), affective information processing patterns (e.g., rigid, negative biases in attention, memory, interpretations, and self-associations), and patient-reported symptoms (perseverative, inflexible thought patterns; inflexible and maladaptive behaviors). Finally, we incorporate discussion of integrative research methods capable of building additional direct empirical support, including using rapid-acting treatments (e.g., ketamine) as a means to test this integrative model by attempting to simultaneously reverse these deficits across levels of analysis.

Indexed as

AnimalsBrainCognitionCognition DisordersCognitive DysfunctionDepressionDepressive DisorderHippocampusHumansMemoryNerve NetNeuronal PlasticityNeuronsPrefrontal CortexStress, Psychological

Identifiers

PMID31801966
PMCPMC7047599
OpenAlexW2994049374

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.