Evidence map›Paper›PMID 31801965›Full record

ArticleMolecular psychiatry2021

The neural and molecular basis of working memory function in psychosis: a multimodal PET-fMRI study.

Faith Borgan, Owen O'Daly, Mattia Veronese, Tiago Reis Marques, Heikki Laurikainen, Jarmo Hietala, Oliver Howes

Open access · hybridAbstract read
In one paragraph

Article in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Memory in Psychiatric Disorders: A Review.Life (Basel, Switzerland) · 2025
    Review
  7. Article
  8. Review
  9. Progress on the application of positron emission tomography imaging of cannabinoid type 1 receptor in neuropsychiatric diseases.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2021
    Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Faith BorganPsychosis Studies Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, England. faith.borgan@kcl.ac.uk.ORCID http://orcid.org/0000-0002-5017-5226
Owen O'DalyCentre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, England.
Mattia VeroneseCentre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, England.ORCID http://orcid.org/0000-0003-3562-0683
Tiago Reis MarquesPsychosis Studies Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, England.ORCID http://orcid.org/0000-0003-0602-7661
Heikki LaurikainenTurku PET Centre, Turku University Hospital, Turku, Finland.
Jarmo HietalaTurku PET Centre, Turku University Hospital, Turku, Finland.
Oliver HowesPsychosis Studies Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, England.
Wellcome Centre for Human Neuroimaging · GBKing's College London · GBUniversity of Turku · FI

Funding

Department of HealthMedical Research Council G0700995Medical Research Council MC_U120097115Medical Research Council MR/L022176/1Medical Research Council MR/N026063/1Medical Research Council MR/N027078/1Wellcome Trust
6 · The paper itself

Abstract

Working memory (WM) deficits predict clinical and functional outcomes in schizophrenia but are poorly understood and unaddressed by existing treatments. WM encoding and WM retrieval have not been investigated in schizophrenia without the confounds of illness chronicity or the use of antipsychotics and illicit substances. Moreover, it is unclear if WM deficits may be linked to cannabinoid 1 receptor dysfunction in schizophrenia. Sixty-six volunteers (35 controls, 31 drug-free patients with diagnoses of schizophrenia or schizoaffective disorder) completed the Sternberg Item-Recognition paradigm during an fMRI scan. Neural activation during WM encoding and WM retrieval was indexed using the blood-oxygen-level-dependent hemodynamic response. A subset of volunteers (20 controls, 20 drug-free patients) underwent a dynamic PET scan to measure [

Indexed as

Memory, Short-TermPsychotic DisordersBrain MappingDorsolateral Prefrontal CortexHumansMagnetic Resonance ImagingMaleMemory DisordersPositron-Emission Tomography

Identifiers

PMID31801965
PMCPMC8550949
OpenAlexW2989722157

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.