Evidence map›Paper›PMID 31801937›Full record

Trial reportTranslational psychiatry2019

Effects of intranasal oxytocin administration on empathy and approach motivation in women with borderline personality disorder: a randomized controlled trial.

Gregor Domes, Nicole Ower, Bernadette von Dawans, Franny B Spengler, Isabel Dziobek, Martin Bohus, Swantje Matthies, Alexandra Philipsen, Markus Heinrichs

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Translational psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
6.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 53 citations in OpenAlex.

  1. Trial
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  3. Impact of social exclusion on empathy in women with borderline personality disorder.European archives of psychiatry and clinical neuroscience · 2023
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  4. Review
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  14. MDMA-Assisted Psychotherapy for Borderline Personality Disorder.Focus (American Psychiatric Publishing) · 2022
    Review
  15. Article
  16. Article
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  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Gregor DomesDepartment of Psychology, Laboratory for Biological and Personality Psychology, University of Freiburg, Freiburg, Germany. domes@uni-trier.de.ORCID http://orcid.org/0000-0001-5908-4374
Nicole OwerDepartment of Psychology, Laboratory for Biological and Personality Psychology, University of Freiburg, Freiburg, Germany.
Bernadette von DawansDepartment of Psychology, Laboratory for Biological and Personality Psychology, University of Freiburg, Freiburg, Germany.ORCID http://orcid.org/0000-0002-7833-7581
Franny B SpenglerDepartment of Psychology, Laboratory for Biological and Personality Psychology, University of Freiburg, Freiburg, Germany.
Isabel DziobekDepartment of Psychology, Clinical Psychology of Social Interaction, Humboldt-Universität zu Berlin, Berlin, Germany.
Martin BohusInstitute of Psychosomatic and Psychiatric Psychotherapy, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany.
Swantje MatthiesDepartment of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.
Alexandra PhilipsenDepartment of Psychiatry and Psychotherapy, University Hospital Bonn, Bonn, Germany.
Markus HeinrichsDepartment of Psychology, Laboratory for Biological and Personality Psychology, University of Freiburg, Freiburg, Germany. heinrichs@psychologie.uni-freiburg.de.
University of Freiburg · DEHarvard University · USHumboldt-Universität zu Berlin · DETrier University of Applied Sciences · DEUniversity Hospital Bonn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Borderline personality disorder (BPD) is characterized by severe interpersonal dysfunction with problems in social cognition, empathy and social approach. Although the neuropeptide oxytocin is known to regulate complex social cognition and behavior in healthy individuals and clinical populations, there is still a lack of evidence for a potential beneficial effect of oxytocin administration on social cognition and social approach in BPD. Fifty-one women with BPD and 51 matched healthy controls were randomized to a double-blind, placebo-controlled, between-subject experimental trial. We administered a single dose of 24 IU oxytocin or placebo intranasally prior to a standardized task measuring affective and cognitive empathy and approach motivation. All participants were free of hormonal contraception and tested in the mid-luteal phase of their menstrual cycle. In the placebo condition, patients with BPD showed reduced cognitive and affective empathy, and less approach behavior motivation than healthy controls. Intranasal oxytocin significantly increased affective empathy and approach motivation in both BPD patients and healthy controls compared to placebo. More importantly, oxytocin administration led to similar scores between BPD and healthy controls. These findings provide the first evidence for a beneficial effect of oxytocin on deficits in affective empathy and approach motivation of BPD. Our results indicate a beneficial effect of a single dose of oxytocin on affective empathy and approach motivation in women with BPD adapting their level of social functioning to healthy controls. Future clinical trials will need to investigate the long-term effects and effectiveness of oxytocin as an add-on treatment for social impairments in BPD.

Indexed as

Administration, IntranasalAdultBorderline Personality DisorderEmpathyFemaleHumansMotivationOxytocinTreatment OutcomeYoung AdultOxytocin

Identifiers

PMID31801937
PMCPMC6892895
OpenAlexW2994491703

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.