ArticleThe Journal of veterinary medical science2020
Molecular diagnosis of bovine B-cell lymphoma using polymerase chain reaction for immunoglobulin heavy chain gene.
Article in The Journal of veterinary medical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Cytological evaluation of bone marrow in 11 cattle with enzootic bovine leukosis.The Journal of veterinary medical science · 2026Article
- A clinical case of enzootic bovine leukosis in a Holstein cow with minor clonality of B-cell in the peripheral blood.The Journal of veterinary medical science · 2024Article
- A clinical case of B-cell lymphoma in a Japanese Black cow with monoclonal proliferation of B-cells as revealed by polymerase chain reaction based on the immunoglobulin light chain gene.The Journal of veterinary medical science · 2024Article
- Infection with bovine leukemia virus belonging to group A or B-1 contributes more strongly to the development of enzootic bovine leukosis in young cattle than the presence of bovine lymphocyte antigen-DRB3 susceptibility alleles.Archives of virology · 2024Article
- Monoclonal proliferation of B-cells with two integration sites of bovine leukemia virus proviral DNA in cattle with enzootic bovine leukosis.The Journal of veterinary medical science · 2024Article
- Enzootic bovine leukosis caused by bovine leukemia virus classified as Group C based on viral whole genome sequencing in a 23-month-old Holstein-Friesian heifer.The Journal of veterinary medical science · 2023Article
- Article
- Time course changes in peripheral B-cell clonality in a Japanese Black bull with enzootic bovine leukosis.The Journal of veterinary medical science · 2022Article
- Enzootic bovine leukosis in a 21-month-old Japanese Black cow with high susceptibility.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2022Article
- Immunoglobulin heavy chain gene rearrangement in heavy chain deposition disease suggests it is a plasma cell disease: a case report.The Journal of international medical research · 2022Review
- Article
- Abnormal clonalities of B-lymphocytes in bovine leukemia virus-infected cattle with persistent lymphocytosis.The Journal of veterinary medical science · 2021Article
- Acute myelomonocytic leukemia negative for alpha-naphthyl acetate esterase stain in a Holstein cow.The Journal of veterinary medical science · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We performed a clonality analysis using polymerase chain reaction (PCR) for immunoglobulin heavy chain (IgH) gene rearrangement, specifically with regard to its utility as a method to diagnose bovine B-cell lymphoma. PCR for IgH gene rearrangement indicated monoclonal proliferation of B-cells in 24 of 35 cattle with B-cell lymphoma. In contrast, PCR for IgH gene rearrangement in lymph nodes and tumor tissues from 65 cattle diagnosed with tumors other than B-cell lymphoma and non-tumors revealed polyclonal population of B-cells. Sensitivity, specificity, positive predictive value, and negative predictive value for PCR for IgH gene rearrangement for bovine B-cell lymphoma were 68.6%, 100%, 100%, and 85.5%, respectively. Clonality analysis using PCR for IgH gene rearrangement may be useful for adjunctive diagnosis of bovine B-cell lymphoma.
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