ArticleScience translational medicine2019
The human tissue-resident CCR5
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In one paragraph
Article in Science translational medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 60 citations in OpenAlex.
- Tissue-resident-like CD4+ T cells secreting IL-17 control Mycobacterium tuberculosis in the human lung.The Journal of clinical investigation · 2021Trial
- Tissue-specific adaptation of human T cells is preserved during tissue inflammation.bioRxiv : the preprint server for biology · 2026Article
- Immune responses in chicken mucosal lymphoid tissues following oral and eye drop vaccination and revaccination with live modified vaccine of infectious laryngotracheitis virus (ILTV).Archives of virology · 2026Article
- Fueling the sentinels: organelle remodeling and metabolic adaptation in tissue-resident memory T cell persistence.Frontiers in immunology · 2026Review
- Divergent cytotoxic and inflammatory functions of intratumoral Vδ2Frontiers in immunology · 2026Article
- Single-cell atlas of the esophageal squamous cell carcinoma immune ecosystem to predict immunotherapy response.Signal transduction and targeted therapy · 2025Article
- Rhinovirus as a driver of airway T cell dynamics in children with treatment-refractory recurrent wheeze.JCI insight · 2025Article
- Tissue-resident immune cells in cervical cancer: emerging roles and therapeutic implications.Frontiers in immunology · 2025Review
- Immunity to Sexually Transmitted Bacterial Infections of the Female Genital Tract: Toward Effective Vaccines.Vaccines · 2024Review
- MAdCAM-1 co-stimulation combined with retinoic acid and TGF-β induces blood CD8Mucosal immunology · 2024Article
- OMIP-102: 50-color phenotyping of the human immune system with in-depth assessment of T cells and dendritic cells.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2024Article
- Signals that control MAIT cell function in healthy and inflamed human tissues.Immunological reviews · 2024Review
- Chronic SIV-Induced neuroinflammation disrupts CCR7+ CD4+ T cell immunosurveillance in the rhesus macaque brain.The Journal of clinical investigation · 2024Article
- PPIH Expression Correlates with Tumor Aggressiveness and Immune Dysregulation in Hepatocellular Carcinoma.Journal of hepatocellular carcinoma · 2024Article
- 50-color phenotyping of the human immune system with in-depth assessment of T cells and dendritic cells.bioRxiv : the preprint server for biology · 2023Article
- Intestinal microbiota-specific Th17 cells possess regulatory properties and suppress effector T cells via c-MAF and IL-10.Immunity · 2023Article
- OMIP-096: A 24-color flow cytometry panel to identify and characterize CD4+ and CD8+ tissue-resident T cells in human skin, intestinal, and type II mucosal tissue.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2023Article
- Enabling Survival of Transplanted Neural Precursor Cells in the Ischemic Brain.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Depleting CD103+ resident memory T cells in vivo reveals immunostimulatory functions in oral mucosa.The Journal of experimental medicine · 2023Article
- CCL5 is a potential bridge between type 1 and type 2 inflammation in asthma.The Journal of allergy and clinical immunology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 6 institutions in 3 countries.
Amanda S Woodward DavisFred Hutchinson Cancer Research Center, Vaccine and Infectious Disease Division, Seattle, WA 98109, USA.ORCID 0000-0002-6901-8271
Hayley N RoozenFred Hutchinson Cancer Research Center, Vaccine and Infectious Disease Division, Seattle, WA 98109, USA.ORCID 0000-0001-6473-962X
Matthew J DufortSystems Immunology Division, Benaroya Research Institute at Virginia Mason, Seattle, WA 98101, USA.ORCID 0000-0002-5200-0040
Hannah A DeBergSystems Immunology Division, Benaroya Research Institute at Virginia Mason, Seattle, WA 98101, USA.ORCID 0000-0002-5263-158X
Martha A DelaneyDepartment of Comparative Medicine, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0002-8465-9958
Florian MairFred Hutchinson Cancer Research Center, Vaccine and Infectious Disease Division, Seattle, WA 98109, USA.ORCID 0000-0001-6732-5449
Jami R EricksonFred Hutchinson Cancer Research Center, Vaccine and Infectious Disease Division, Seattle, WA 98109, USA.ORCID 0000-0002-4549-5217
Chloe K SlichterFred Hutchinson Cancer Research Center, Vaccine and Infectious Disease Division, Seattle, WA 98109, USA.
Julia D BerksonFred Hutchinson Cancer Research Center, Vaccine and Infectious Disease Division, Seattle, WA 98109, USA.ORCID 0000-0003-3296-9740
Alexis M KlockDepartment of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0002-5252-5920
Matthias MackDepartment of Internal Medicine-Nephrology, University Hospital Regensburg, 93053 Regensburg, Germany.
Yu LwoDepartment of Periodontics, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0002-3112-321X
Alexander KoDepartment of Periodontics, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0002-1713-5636
Rhonda M BrandDepartment of Internal Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.ORCID 0000-0002-3963-6909
Ian McGowanUniversity of Miami Miller School of Medicine, Miami, FL 33136, USA.ORCID 0000-0002-6470-8476
Peter S LinsleySystems Immunology Division, Benaroya Research Institute at Virginia Mason, Seattle, WA 98101, USA.ORCID 0000-0002-8960-4307
Douglas R DixonDepartment of Periodontics, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0003-0911-3717
Martin PrlicFred Hutchinson Cancer Research Center, Vaccine and Infectious Disease Division, Seattle, WA 98109, USA. mprlic@fredhutch.org.ORCID 0000-0002-0685-9321
University of Washington · USFred Hutch Cancer Center · USVirginia Mason Medical Center · USUniversity Hospital Regensburg · DEUniversity of Miami · USUniversity of Pittsburgh · US
Funding
TRAINING IN MOLECULAR AND CELLULAR BIOLOGYT32GM007270 · NIGMS · UNIVERSITY OF WASHINGTON · PI RAIBLE, DAVID W · 1985 to 2020
$21.0MVENEREAL DISEASET32AI007140 · NIAID · UNIVERSITY OF WASHINGTON · PI Julia Cook Dombrowski · 1985 to 2026
$19.4MTopical Antiretrovirals to Prevent Rectal HIV InfectionU19AI082637 · NIAID · MAGEE-WOMEN'S RES INST AND FOUNDATION · PI GABELNICK, HENRY L · 2009 to 2013
$11.1MDiseases of Public Health Importance Training GrantT32AI007509 · NIAID · UNIVERSITY OF WASHINGTON · PI LUND, JENNIFER M · 1997 to 2024
$6.3MInflammation-driven T Cell Responses and their Dichotomous Effect on Host ImmunityR01AI123323 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PRLIC, MARTIN · 2017 to 2025
$5.0MPaving the Way for a Novel Therapeutic Approach to Combat HIVDP2DE023321 · NIDCR · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PRLIC, MARTIN · 2012 to 2014
$2.9MThe effect of peri-mucositis and peri-implantitis on innate-like T cell function and anti-bacterial immunityR21DE026565 · NIDCR · FRED HUTCHINSON CANCER RESEARCH CENTER · PI DIXON, DOUGLAS RAYMOND, PRLIC, MARTIN · 2017 to 2018
$488kNIAID NIH HHS R01 AI123323NIAID NIH HHS T32 AI007140NIAID NIH HHS T32 AI007509NIAID NIH HHS U19 AI082637NIDCR NIH HHS DP2 DE023321NIDCR NIH HHS R21 DE026565NIGMS NIH HHS T32 GM007270
Abstract
CCR5 is thought to play a central role in orchestrating migration of cells in response to inflammation. CCR5 antagonists can reduce inflammatory disease processes, which has led to an increased interest in using CCR5 antagonists in a wide range of inflammation-driven diseases. Paradoxically, these antagonists appear to function without negatively affecting host immunity at barrier sites. We reasoned that the resolution to this paradox may lie in the CCR5
Indexed as
Cell CompartmentationAdolescentAdultAgedAged, 80 and overAntigens, CDAntigens, Differentiation, T-LymphocyteCD69 AntigensCD8-Positive T-LymphocytesCytokinesFemaleHumansInflammationLectins, C-TypeLymphocyte SubsetsMaleAntigens, CDAntigens, Differentiation, T-LymphocyteCCR5 protein, humanCD69 AntigensCytokinesLectins, C-TypeMaravirocReceptors, Antigen, T-CellReceptors, CCR5
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.