Evidence map›Paper›PMID 31801865›Full record

ArticleJournal of virology2020

Kaposi's Sarcoma-Associated Herpesvirus LANA Modulates the Stability of the E3 Ubiquitin Ligase RLIM.

Hagar Tadmor, Melanie Greenway, Anuj Ahuja, Ola Orgil, Gangling Liao, Richard F Ambinder, S Diane Hayward, Meir Shamay

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. PDLIM2: Signaling pathways and functions in cancer suppression and host immunity.Biochimica et biophysica acta. Reviews on cancer · 2021
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Hagar TadmorDaniella Lee Casper Laboratory in Viral Oncology, Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.
Melanie GreenwayViral Oncology Program, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Anuj AhujaDaniella Lee Casper Laboratory in Viral Oncology, Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.
Ola OrgilDaniella Lee Casper Laboratory in Viral Oncology, Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.
Gangling LiaoViral Oncology Program, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Richard F AmbinderViral Oncology Program, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
S Diane HaywardViral Oncology Program, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Meir ShamayDaniella Lee Casper Laboratory in Viral Oncology, Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel meir.shamay@biu.ac.il.ORCID 0000-0003-0223-2852
Bar-Ilan University · ILJohns Hopkins University · US

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI Rosalie Wollett · 1985 to 2026
$208.6M
Targeting Kinases that Phosphorylate the KSHV LANA Chromatin Binding DomainR21CA171814 · NCI · JOHNS HOPKINS UNIVERSITY · PI HAYWARD, S DIANE · 2012 to 2013
$377k
NCI NIH HHS P30 CA006973NCI NIH HHS R21 CA171814
6 · The paper itself

Abstract

The Kaposi's sarcoma-associated herpesvirus (KSHV)-encoded latency-associated nuclear antigen (LANA) protein functions in latently infected cells as an essential participant in KSHV genome replication and as a driver of dysregulated cell growth. In a previous study, we have identified LANA-interacting proteins using a protein array screen. Here, we explore the effect of LANA on the stability and activity of RLIM (RING finger LIM-domain-interacting protein, encoded by the

Indexed as

AnimalsAntigens, NuclearAntigens, ViralCell LineCHO CellsCricetulusDNA-Binding ProteinsGene Expression RegulationHEK293 CellsHerpesvirus 8, HumanHumansLIM Domain ProteinsLIM-Homeodomain ProteinsNuclear ProteinsSarcoma, KaposiTelomeric Repeat Binding Protein 1Antigens, NuclearAntigens, ViralDNA-Binding Proteinslatency-associated nuclear antigenlatent Orf73 antigen, human herpesvirus 8LDB1 protein, humanLhx3 proteinLIM Domain ProteinsLIM-Homeodomain ProteinsNuclear ProteinsRLIM protein, humanTelomeric Repeat Binding Protein 1Transcription FactorsUbiquitin-Protein LigasesViral ProteinsE3 ubiquitin ligaseKaposi's sarcomaKaposi's sarcoma-associated herpesvirusLANALDB1ORF73RLIM

Identifiers

PMID31801865
PMCPMC7022369
OpenAlexW2994236786

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.