Evidence map›Paper›PMID 31801721›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2019

[Long non-coding RNAs show different expression profiles and display competing endogenous RNA potential in placenta accreta spectrum disorders].

Shuzhen Wu, Huishan Zhang, Yan Liu, Rui Wang, Shaoxin Ye, Meng Zeng, Zhengping Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Shuzhen WuDepartment of Obstetrics, Foshan Maternal and Child Health Hospital Affiliated to Southern Medical University, Foshan 528000, China.
Huishan ZhangDepartment of Obstetrics, Foshan Maternal and Child Health Hospital Affiliated to Southern Medical University, Foshan 528000, China.
Yan LiuDepartment of Obstetrics, Foshan Maternal and Child Health Hospital Affiliated to Southern Medical University, Foshan 528000, China.
Rui WangDepartment of Obstetrics, Foshan Maternal and Child Health Hospital Affiliated to Southern Medical University, Foshan 528000, China.
Shaoxin YeDepartment of Obstetrics, Foshan Maternal and Child Health Hospital Affiliated to Southern Medical University, Foshan 528000, China.
Meng ZengDepartment of Obstetrics, Foshan Maternal and Child Health Hospital Affiliated to Southern Medical University, Foshan 528000, China.
Zhengping LiuDepartment of Obstetrics, Foshan Maternal and Child Health Hospital Affiliated to Southern Medical University, Foshan 528000, China.
Foshan Maternity and Child Health Care Hospital · CNFoshan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the expression profile of long non-coding RNAs (lncRNA) and identify potential lncRNA-related competing endogenous RNAs (ceRNA) in placenta accrete spectrum disorders (PAS).

methodsFive tissue specimens of placental implantation and 5 adjacent normal placental tissues were collected from cesarean section deliveries complicated by PAS in our hospital between December, 2017 and June, 2018. Human microarrays were used to identify the lncRNAs that were differentially expressed in PAS, and 5 of the identified lncRNAs were further validated using qRT-PCR. GO and KEGG pathway analyses were performed to indentify the most significant enrichment functions. A ceRNA network was constructed based on ENST00000511361 (RP5-875H18.4), NR_027457 (LINC00221) and NR_126415 (FOXP4-AS1) to pinpoint the potential lncRNAs-related ceRNA.

resultsA total of 329 lncRNAs and 179 mRNAs were identified to have differential expression in PAS. The results of qRT-PCR were consistent with the human microarrays results. Transforming growth factor-β (TGF-β) signaling pathway was the most significantly enriched pathway. The constructed ceRNA network suggested that RP5-875H18.4--miRNA-218--SLIT2 had a potential ceRNA regulatory mechanism in PAS.

conclusionsThe differentially expressed lncRNAs are involved in the occurrence and progression of PAS possibly by regulating the TGF-β signaling pathway. The ceRNA network of RP5-875H18.4--miRNA-218--SLIT2 may play a role in the occurrence of PAS.

Indexed as

Cesarean SectionFemaleGene Regulatory NetworksHumansIntercellular Signaling Peptides and ProteinsMicroRNAsNerve Tissue ProteinsPlacenta AccretaPregnancyRNA, Long NoncodingSignal TransductionSlit Homolog 2 ProteinTransforming Growth Factor betaIntercellular Signaling Peptides and ProteinsMicroRNAsMIRN218 microRNA, humanNerve Tissue ProteinsRNA, Long NoncodingSlit Homolog 2 ProteinTransforming Growth Factor betacompeting endogenous RNA networkexpression profilelong non-coding RNAsplacenta accreta spectrum

Identifiers

PMID31801721
PMCPMC6867958
OpenAlexW2999808440

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.