ArticleClinical nutrition (Edinburgh, Scotland)2020
Hyperosmolar dehydration: A predictor of kidney injury and outcome in hospitalised older adults.
Article in Clinical nutrition (Edinburgh, Scotland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Acute kidney injury biomarker responses in young and older female adults following mild hypohydration.American journal of physiology. Renal physiology · 2026Trial
- Trial
- Underdocumentation of laboratory-defined acute kidney injury in internal medicine wards: a retrospective cohort study.Renal failure · 2026Article
- Elevated serum osmolarity is associated with 28-day all-cause mortality in patients with cardiac arrest.World journal of emergency medicine · 2026Article
- Prevalence of low-intake dehydration in hospitalised older adults: systematic review and meta-analysis.BMJ public health · 2026Article
- Association between serum osmolality trajectories and mortality in sepsis patients: a retrospective multi-cohort study.European journal of medical research · 2025Article
- Article
- Association between serum osmolality and chronic kidney disease prevalence: Evidence from NHANES 1999-2018.Scientific reports · 2025Article
- Development and evaluation of a rapid skin taurine measurement device using skin blotting for the early detection of dehydration.Japan journal of nursing science : JJNS · 2025Article
- Predictive ability of serum osmolarity for contrast-induced nephropathy after elective percutaneous coronary intervention: Are we having a new target?The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2025Article
- The relevance of acute kidney injury in dehydrated children.Frontiers in pediatrics · 2025Review
- Association between serum osmolality and deteriorating renal function in patients with acute myocardial infarction: analysis of the MIMIC- IV database.BMC cardiovascular disorders · 2024Article
- Prevention of Chronic Kidney Disease and Its Complications in Older Adults.Drugs & aging · 2024Review
- Anemia and Its Connections to Inflammation in Older Adults: A Review.Journal of clinical medicine · 2024Review
- The Association Between Dehydration and the Prognosis of Sudden Sensorineural Hearing Loss.Otology & neurotology open · 2023Article
- The association between plasma osmolality and in-hospital mortality in the first 24 h after neonatal intensive care unit admission.Frontiers in pediatrics · 2023Article
- Influence of Impaired Hydration Status on Postoperative in-Hospital Death in Patients with Acute Type A Aortic Dissection.International journal of general medicine · 2023Article
- Increased ICU mortality in septic shock patients with hypo- or hyper- serum osmolarity: A retrospective study.Frontiers in medicine · 2023Article
- The Missing Link Between Coffee Consumption and AKI-Water.Kidney international reports · 2022Article
- Advantages in Management and Remote Monitoring of Intravenous Therapy: Exploratory Survey and Economic Evaluation of Gravity-Based Infusions in Finland.Advances in therapy · 2022Article
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5 authors.
Funding
Abstract
BACKGROUND &
aimsHospitalised older adults are vulnerable to dehydration. However, the prevalence of hyperosmolar dehydration (HD) and its impact on outcome is unknown. Serum osmolality is not measured routinely but osmolarity, a validated alternative, can be calculated using routinely measured serum biochemistry. This study aimed to use calculated osmolarity to measure the prevalence of HD (serum osmolarity >300 mOsm/l) and assess its impact on acute kidney injury (AKI) and outcome in hospitalised older adults.
methodsThis retrospective cohort study used data from a UK teaching hospital retrieved from the electronic database relating to all medical emergency admissions of patients aged ≥ 65 years admitted between 1st May 2011 and 31st October 2013. Using these data, Charlson comorbidity index (CCI), National Early Warning Score (NEWS), length of hospital stay (LOS) and mortality were determined. Osmolarity was calculated using the equation of Krahn and Khajuria.
resultsA total of 6632 patients were identified; 27% had HD, 39% of whom had AKI. HD was associated with a median (Q1, Q3) LOS of 5 (1, 12) days compared with 3 (1, 9) days in the euhydrated group, P < 0.001. Adjusted Cox-regression analysis demonstrated that patients with HD were four-times more likely to develop AKI 12-24 h after admission [Hazards Ratio (95% Confidence Interval) 4.5 (3.5-5.6), P < 0.001], and had 60% greater 30-day mortality [1.6 (1.4-1.9), P < 0.001], compared with those who were euhydrated.
conclusionHD is common in hospitalised older adults and is associated with increased LOS, risk of AKI and mortality. Further work is required to assess the validity of osmolality or osmolarity as an early predictor of AKI and the impact of HD on outcome prospectively.
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