Evidence map›Paper›PMID 31801465›Full record

ArticleBMC pregnancy and childbirth2019

Potentially modifiable predictors of adverse neonatal and maternal outcomes in pregnancies with gestational diabetes mellitus: can they help for future risk stratification and risk-adapted patient care?

Maria-Christina Antoniou, Leah Gilbert, Justine Gross, Jean-Benoît Rossel, Céline J Fischer Fumeaux, Yvan Vial, Jardena J Puder

Abstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pregnancy and childbirth, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Effect of theFrontiers in endocrinology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Maria-Christina AntoniouPediatric Service, Department Woman-Mother-Child, Lausanne University Hospital, Lausanne, Switzerland. maria-christina.antoniou@chuv.ch.
Leah GilbertObstetric Service, Department Woman-Mother-Child, Lausanne University Hospital, Lausanne, Switzerland.
Justine GrossObstetric Service, Department Woman-Mother-Child, Lausanne University Hospital, Lausanne, Switzerland.
Jean-Benoît RosselObstetric Service, Department Woman-Mother-Child, Lausanne University Hospital, Lausanne, Switzerland.
Céline J Fischer FumeauxPediatric Service, Department Woman-Mother-Child, Lausanne University Hospital, Lausanne, Switzerland.
Yvan VialObstetric Service, Department Woman-Mother-Child, Lausanne University Hospital, Lausanne, Switzerland.
Jardena J PuderObstetric Service, Department Woman-Mother-Child, Lausanne University Hospital, Lausanne, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGestational diabetes mellitus (GDM) exposes mothers and their offspring to short and long-term complications. The objective of this study was to identify the importance of potentially modifiable predictors of adverse outcomes in pregnancies with GDM. We also aimed to assess the relationship between maternal predictors and pregnancy outcomes depending on HbA1c values and to provide a risk stratification for adverse pregnancy outcomes according to the prepregnancy BMI (Body mass index) and HbA1c at the 1st booking.

methodsThis prospective study included 576 patients with GDM. Predictors were prepregnancy BMI, gestational weight gain (GWG), excessive weight gain, fasting, 1 and 2-h glucose values after the 75 g oral glucose challenge test (oGTT), HbA1c at the 1st GDM booking and at the end of pregnancy and maternal treatment requirement. Maternal and neonatal outcomes such as cesarean section, macrosomia, large and small for gestational age (LGA, SGA), neonatal hypoglycemia, prematurity, hospitalization in the neonatal unit and Apgar score at 5 min < 7 were evaluated. Univariate and multivariate regression analyses and probability analyses were performed.

resultsOne-hour glucose after oGTT and prepregnancy BMI were correlated with cesarean section. GWG and HbA1c at the end pregnancy were associated with macrosomia and LGA, while prepregnancy BMI was inversely associated with SGA. The requirement for maternal treatment was correlated with neonatal hypoglycemia, and HbA1c at the end of pregnancy with prematurity (all p < 0.05). The correlations between predictors and pregnancy complications were exclusively observed when HbA1c was ≥5.5% (37 mmol/mol). In women with prepregnancy BMI ≥ 25 kg/m

conclusionsPrepregnancy BMI, GWG, maternal treatment requirement and HbA1c at the end of pregnancy can predict adverse pregnancy outcomes in women with GDM, particularly when HbA1c is ≥5.5% (37 mmol/mol). Stratification based on prepregnancy BMI and HbA1c at the 1st booking may allow for future risk-adapted care in these patients.

Indexed as

Body Mass IndexAdultBiomarkersBirth WeightDiabetes, GestationalFemaleFetal MacrosomiaGestational Weight GainGlucose Tolerance TestGlycated HemoglobinHumansInfant, NewbornInfant, Small for Gestational AgePredictive Value of TestsPregnancyPregnancy OutcomeBiomarkersGlycated Hemoglobinhemoglobin A1c protein, humanGestational diabetesHbA1cPregnancy outcomesRisk stratification

Identifiers

PMID31801465
PMCPMC6894261

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.