ArticleJournal of the American Heart Association2019
miR-181c Activates Mitochondrial Calcium Uptake by Regulating MICU1 in the Heart.
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Article in Journal of the American Heart Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
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Who cites it
30 citing papers in PubMed, 33 citations in OpenAlex.
- MicroRNAs in Cardiovascular Diseases: Molecular Networks of Cellular Homeostasis, Inflammation, and Pathological Remodeling.International journal of molecular sciences · 2026Review
- Mitochondrial miRNA- miR-181c-5p and mitomiR-106a-5p levels as indicators in cardiovascular disease patients.Molecular biology reports · 2026Article
- The Role of MicroRNAs in Mitochondrial Homeostasis and their Involvement in the Pathogenesis of Obesity and Metabolic Syndrome: A Focus on MicroRNAs.Current medicinal chemistry · 2026Review
- Mechanisms of microRNA trafficking to mitochondria in the heart.Current opinion in physiology · 2025Article
- Mitochondrial targets in ischaemic heart disease and heart failure, and their potential for a more efficient clinical translation. A scientific statement of the ESC Working Group on Cellular Biology of the Heart and the ESC Working Group on Myocardial Function.European journal of heart failure · 2025Review
- 2-aminoethoxydiphenylborane intervenes intracellular calcium signaling and attenuates myocardial ischemia-reperfusion injury in mice through ITPR1/MCU pathway.Scientific reports · 2025Article
- Mitochondria-Associated Organelle Crosstalk in Myocardial Ischemia/Reperfusion Injury.Journal of cardiovascular translational research · 2024Review
- Sex-dependent phosphorylation of Argonaute 2 reduces the mitochondrial translocation of miR-181c and induces cardioprotection in females.Journal of molecular and cellular cardiology · 2024Article
- MICU1 and MICU2 control mitochondrial calcium signaling in the mammalian heart.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Role of Specificity Protein 1 (SP1) in Cardiovascular Diseases: Pathological Mechanisms and Therapeutic Potentials.Biomolecules · 2024Review
- Mitochondrial calcium uniporter channel gatekeeping in cardiovascular disease.Nature cardiovascular research · 2024Review
- Cold stress-induced ferroptosis in liver sinusoidal endothelial cells determines liver transplant injury and outcomes.JCI insight · 2024Article
- Role of post-translational modifications of Sp1 in cardiovascular diseases.Frontiers in cell and developmental biology · 2024Review
- Divergent cardiac and renal effects of miR-181c-5p inhibition in a rodent heart failure model.Frontiers in cardiovascular medicine · 2024Article
- The miR-181 family: Wide-ranging pathophysiological effects on cell fate and function.Journal of cellular physiology · 2023Review
- Mitochondrial epigenetics in aging and cardiovascular diseases.Frontiers in cardiovascular medicine · 2023Review
- Mitochondrion-targeted RNA therapies as a potential treatment strategy for mitochondrial diseases.Molecular therapy. Nucleic acids · 2022Review
- Mitochondrial calcium exchange in physiology and disease.Physiological reviews · 2022Review
- CaPflugers Archiv : European journal of physiology · 2022Review
- Long Noncoding RNA RMRP Contributes to Paclitaxel Sensitivity of Ovarian Cancer by Regulating miR-580-3p/MICU1 Signaling.Journal of oncology · 2022Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Hemanth N BanavathDepartment of Pathology Johns Hopkins School of Medicine Baltimore MD.
Barbara RomanDepartment of Pathology Johns Hopkins School of Medicine Baltimore MD.
Nathan MackowskiDepartment of Environmental Health and Engineering Johns Hopkins Bloomberg School of Public Health Baltimore MD.
Debjit BiswasDepartment of Pathology Johns Hopkins School of Medicine Baltimore MD.
Junaid AfzalDepartment of Medicine UCSF School of Medicine San Francisco CA.
Yohei NomuraDivision of Cardiac Surgery Department of Surgery Johns Hopkins School of Medicine Baltimore MD.
Soroosh SolhjooDepartment of Pathology Johns Hopkins School of Medicine Baltimore MD.
Brian O'RourkeDivision of Cardiology Department of Medicine Johns Hopkins School of Medicine Baltimore MD.
Mark KohrDepartment of Environmental Health and Engineering Johns Hopkins Bloomberg School of Public Health Baltimore MD.
Elizabeth MurphyCardiac Physiology Section National Heart, Lung, and Blood Institute NIH Bethesda MD.
Charles SteenbergenDepartment of Pathology Johns Hopkins School of Medicine Baltimore MD.
Samarjit DasDepartment of Pathology Johns Hopkins School of Medicine Baltimore MD.
Johns Hopkins University · USJohns Hopkins Medicine · USNational Heart Lung and Blood Institute · USUniversity of California, San Francisco · US
Funding
PATHOPHYSIOLOGY OF MYOCARDIAL DISEASEST32HL007227 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Chulan Kwon, WENDY S POST · 1985 to 2026
$21.2MELEVATED CALCIUM AND MYOCARDIAL ISCHEMIC INJURYR01HL039752 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI STEENBERGEN, CHARLES · 1993 to 2019
$6.6MTargeting Metabo-Redox Network Vulnerability in Heart Failure and Sudden DeathR01HL134821 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI FOSTER, D BRIAN, O'ROURKE, BRIAN · 2018 to 2021
$2.1MS-nitrosation in cell survival and cell deathR01HL136496 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI KOHR, MARK JEFFREY · 2018 to 2022
$2.0MMolecular Determinants of Mitochondrial Instability and ArrhythmiasR01HL137259 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI AKAR, FADI GABRIEL, O'ROURKE, BRIAN · 2017 to 2020
$2.0MAmerican Heart Association-American Stroke Association 14SDG18890049NHLBI NIH HHS R01 HL039752NHLBI NIH HHS R01 HL134821NHLBI NIH HHS R01 HL136496NHLBI NIH HHS R01 HL137259NHLBI NIH HHS T32 HL007227
Abstract
Background Translocation of miR-181c into cardiac mitochondria downregulates the mitochondrial gene, mt-COX1. miR-181c/d
Indexed as
AnimalsCalciumCalcium-Binding ProteinsMaleMiceMice, Inbred C57BLMicroRNAsMitochondria, HeartMitochondrial Membrane Transport ProteinsCalciumCalcium-Binding ProteinsMicroRNAsMICU1 protein, mousemirn181 microRNA, mouseMitochondrial Membrane Transport Proteinsheart failuremicroRNAmiRNAmitochondriamitochondrial calciummitomiR
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.