Evidence map›Paper›PMID 31801264›Full record

ArticleInternational journal of molecular sciences2019

DeepMiR2GO: Inferring Functions of Human MicroRNAs Using a Deep Multi-Label Classification Model.

Jiacheng Wang, Jingpu Zhang, Yideng Cai, Lei Deng

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. SDN2GO: An Integrated Deep Learning Model for Protein Function Prediction.Frontiers in bioengineering and biotechnology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Jiacheng WangSchool of Computer Science and Engineering, Central South University, Changsha 410083, China.
Jingpu ZhangSchool of Computer and Data Science, Henan University of Urban Construction, Pingdingshan 467000, China.ORCID 0000-0002-8006-747X
Yideng CaiSchool of Computer Science and Engineering, Central South University, Changsha 410083, China.
Lei DengSchool of Computer Science and Engineering, Central South University, Changsha 410083, China.ORCID 0000-0003-2869-1619
Central South University · CNHenan University of Urban Construction · CN

Funding

National Natural Science Foundation of China 61672541National Natural Science Foundation of China 61972422
6 · The paper itself

Abstract

MicroRNAs (miRNAs) are a highly abundant collection of functional non-coding RNAs involved in cellular regulation and various complex human diseases. Although a large number of miRNAs have been identified, most of their physiological functions remain unknown. Computational methods play a vital role in exploring the potential functions of miRNAs. Here, we present DeepMiR2GO, a tool for integrating miRNAs, proteins and diseases, to predict the gene ontology (GO) functions based on multiple deep neuro-symbolic models. DeepMiR2GO starts by integrating the miRNA co-expression network, protein-protein interaction (PPI) network, disease phenotype similarity network, and interactions or associations among them into a global heterogeneous network. Then, it employs an efficient graph embedding strategy to learn potential network representations of the global heterogeneous network as the topological features. Finally, a deep multi-label classification network based on multiple neuro-symbolic models is built and used to annotate the GO terms of miRNAs. The predicted results demonstrate that DeepMiR2GO performs significantly better than other state-of-the-art approaches in terms of precision, recall, and maximum F-measure.

Indexed as

Neural Networks, ComputerCardiovascular DiseasesDatasets as TopicGene Expression RegulationGene OntologyGene Regulatory NetworksHumansMicroRNAsNeoplasmsSchizophreniaMicroRNAsdeep multi-label classificationgraph embeddingheterogeneous networkMicroRNA function

Identifiers

PMID31801264
PMCPMC6928926
OpenAlexW2990809140

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.